An attenuated coxsackievirus B5 mutant carrying VP1-N157K retains oncolytic potency against non-small cell lung cancer

An attenuated coxsackievirus B5 mutant carrying VP1-N157K retains oncolytic potency against non-small cell lung cancer

Oncolytic virus therapy is a rapidly developing cancer treatment method. The development of oncolytic viruses often involves genetic modifications, such as increased expression of foreign proteins for enhancing the antitumor capabilities and knocking out of virulence loci for improving the safety. T...

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Bibliographic Details
Main Authors: Lifang Song, Bopei Cui, Qiushuang Gao, Chaoying Hu, Qian wang, Jialu Zhang, Yajing Li, Guanxing Liu, Yulong Fu, Ying Wang, Kelei Li, Xiaotian Hao, Fan Gao, Xing Wu, Qunying Mao, Zhenglun Liang, Yongxin Yu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
oncolytic virus
reverse genetics
virulence
safety
coxsackievirus
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329925000682
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