Impact of cell culture transition on adipose-derived mesenchymal stromal cells: Multi-omics analysis of small- vs large-scale production

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Impact of cell culture transition on adipose-derived mesenchymal stromal cells: Multi-omics analysis of small- vs large-scale production

Mesenchymal stromal cells (MSCs) are being tested in numerous clinical trials, yet the limited progression of these trials to advanced stages indicates unresolved translational challenges. Expanding MSCs is a critical step in most therapeutic applications, and bioreactor-based culture offers large-s...

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Main Authors:	Marina Ramírez Galera, Athanasios Oikonomou, Jonas D. Elsborg, Lisa Harth, Anne Fischer-Nielsen, Marianne Bengtson Løvendorf, Beatrice Dyring-Andersen, Francesco Iorio, Lea Munthe Fog, Anders Woetmann, Jesper Dyrendom Svalgaard
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Series:	Molecular Therapy: Methods & Clinical Development
Subjects:	adipose-derived mesenchymal stromal cells AD-MSCs MSCs cell expansion large-scale cell production bioreactor
Online Access:	http://www.sciencedirect.com/science/article/pii/S232905012500107X
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