Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for osteoporosis

Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for osteoporosis

Objectives: The aim of this study was to find potential drug targets of osteoporosis (OP) through systematic druggable genome-wide Mendelian randomization (MR) analysis. Methods: Combining the multi-omics data, we utilized drug target MR and mediation MR to search for potential drug targets of OP an...

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Bibliographic Details
Main Authors: Chiyun Sun, Ruikang Liu, Jiaming Hu, Weiming Fan, Chuanrui Sun, Pengcheng Shan, Xu Wei
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Osteoporosis and Sarcopenia
Subjects:
Druggable genes
Mendelian randomization
Osteoporosis
Drug target
Multi-omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2405525525000342
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