Algorithm for the selection of drugs for targeted antimicrobial therapy based on the results of molecular biological studies of positive blood cultures
Cardinal changes in approaches to the choice of antimicrobial therapy for severe infections have occurred in recent years. They are associated with the growth of antibiotic resistance of nosocomial pathogens and the lack of sufficiently effective «universal» schemes of empirical antibiotic therapy....
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2023-05-01
|
| Series: | Вестник анестезиологии и реаниматологии |
| Subjects: | |
| Online Access: | https://www.vair-journal.com/jour/article/view/800 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839581135440445440 |
|---|---|
| author | А. V. Dekhnich A. Yu. Kuzmenkov D. A. Popov I. V. Shlyk M. V. Edelshtein |
| author_facet | А. V. Dekhnich A. Yu. Kuzmenkov D. A. Popov I. V. Shlyk M. V. Edelshtein |
| author_sort | А. V. Dekhnich |
| collection | DOAJ |
| description | Cardinal changes in approaches to the choice of antimicrobial therapy for severe infections have occurred in recent years. They are associated with the growth of antibiotic resistance of nosocomial pathogens and the lack of sufficiently effective «universal» schemes of empirical antibiotic therapy. Recent international and domestic recommendations focus on a «pathogen-specific» approach aimed at the treatment of infections caused by specific problematic resistant pathogens. The application of such «pathogen-specific» recommendations is not possible without the availability of appropriate quality microbiological data. The further evolution of diagnostic methods is directed creating test systems that allow detecting the main pathogens of infection and the most important antibiotic resistance genes, allowing to reduce the time from the moment of taking clinical material for microbiological examination to obtaining the result that affects the choice of antibiotic therapy regimen. The review contains practical recommendations on the choice of drugs for targeted antimicrobial therapy based on the clinical interpretation of the results obtained using the «hyperplex» panel BioFire BCID2 (Blood Culture Identification 2BCID2), taking into account the statements set out in the guidelines «Diagnosis and antimicrobial therapy for infections caused by polyresistant strains of microorganisms». |
| format | Article |
| id | doaj-art-c542c1f12da04890b4acf6b45d25df81 |
| institution | Matheson Library |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2023-05-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-c542c1f12da04890b4acf6b45d25df812025-08-04T10:20:48ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532023-05-012029610710.24884/2078-5658-2022-20-2-96-107598Algorithm for the selection of drugs for targeted antimicrobial therapy based on the results of molecular biological studies of positive blood culturesА. V. Dekhnich0A. Yu. Kuzmenkov1D. A. Popov2I. V. Shlyk3M. V. Edelshtein4Smolensk State Medical UniversitySmolensk State Medical UniversityA. N. Bakulev National Medical Research Center of Cardiovascular SurgeryPavlov UniversitySmolensk State Medical UniversityCardinal changes in approaches to the choice of antimicrobial therapy for severe infections have occurred in recent years. They are associated with the growth of antibiotic resistance of nosocomial pathogens and the lack of sufficiently effective «universal» schemes of empirical antibiotic therapy. Recent international and domestic recommendations focus on a «pathogen-specific» approach aimed at the treatment of infections caused by specific problematic resistant pathogens. The application of such «pathogen-specific» recommendations is not possible without the availability of appropriate quality microbiological data. The further evolution of diagnostic methods is directed creating test systems that allow detecting the main pathogens of infection and the most important antibiotic resistance genes, allowing to reduce the time from the moment of taking clinical material for microbiological examination to obtaining the result that affects the choice of antibiotic therapy regimen. The review contains practical recommendations on the choice of drugs for targeted antimicrobial therapy based on the clinical interpretation of the results obtained using the «hyperplex» panel BioFire BCID2 (Blood Culture Identification 2BCID2), taking into account the statements set out in the guidelines «Diagnosis and antimicrobial therapy for infections caused by polyresistant strains of microorganisms».https://www.vair-journal.com/jour/article/view/800bacteremiasepsisantibiotic therapyantibiotic resistancediagnosticspcr |
| spellingShingle | А. V. Dekhnich A. Yu. Kuzmenkov D. A. Popov I. V. Shlyk M. V. Edelshtein Algorithm for the selection of drugs for targeted antimicrobial therapy based on the results of molecular biological studies of positive blood cultures Вестник анестезиологии и реаниматологии bacteremia sepsis antibiotic therapy antibiotic resistance diagnostics pcr |
| title | Algorithm for the selection of drugs for targeted antimicrobial therapy based on the results of molecular biological studies of positive blood cultures |
| title_full | Algorithm for the selection of drugs for targeted antimicrobial therapy based on the results of molecular biological studies of positive blood cultures |
| title_fullStr | Algorithm for the selection of drugs for targeted antimicrobial therapy based on the results of molecular biological studies of positive blood cultures |
| title_full_unstemmed | Algorithm for the selection of drugs for targeted antimicrobial therapy based on the results of molecular biological studies of positive blood cultures |
| title_short | Algorithm for the selection of drugs for targeted antimicrobial therapy based on the results of molecular biological studies of positive blood cultures |
| title_sort | algorithm for the selection of drugs for targeted antimicrobial therapy based on the results of molecular biological studies of positive blood cultures |
| topic | bacteremia sepsis antibiotic therapy antibiotic resistance diagnostics pcr |
| url | https://www.vair-journal.com/jour/article/view/800 |
| work_keys_str_mv | AT avdekhnich algorithmfortheselectionofdrugsfortargetedantimicrobialtherapybasedontheresultsofmolecularbiologicalstudiesofpositivebloodcultures AT ayukuzmenkov algorithmfortheselectionofdrugsfortargetedantimicrobialtherapybasedontheresultsofmolecularbiologicalstudiesofpositivebloodcultures AT dapopov algorithmfortheselectionofdrugsfortargetedantimicrobialtherapybasedontheresultsofmolecularbiologicalstudiesofpositivebloodcultures AT ivshlyk algorithmfortheselectionofdrugsfortargetedantimicrobialtherapybasedontheresultsofmolecularbiologicalstudiesofpositivebloodcultures AT mvedelshtein algorithmfortheselectionofdrugsfortargetedantimicrobialtherapybasedontheresultsofmolecularbiologicalstudiesofpositivebloodcultures |