THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A>G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN
Objective: to study associations between VDR gene 283 A>G (BsmI) polymorphism and osteoporotic changes in various sites of skeleton in postmenopausal women. Materials and methods: 525 postmenopausal women were examined. The densitometry was carried out by dual energy X-ray absorptiometry. VDR...
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2016-12-01
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| Series: | Медицинский вестник Юга России |
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| Online Access: | https://www.medicalherald.ru/jour/article/view/463 |
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| author | E. A. Maylyan |
| author_facet | E. A. Maylyan |
| author_sort | E. A. Maylyan |
| collection | DOAJ |
| description | Objective: to study associations between VDR gene 283 A>G (BsmI) polymorphism and osteoporotic changes in various sites of skeleton in postmenopausal women. Materials and methods: 525 postmenopausal women were examined. The densitometry was carried out by dual energy X-ray absorptiometry. VDR gene 283 A>G (BsmI) polymorphism was investigated by the realtime PCR method. Results: this investigation determined correlation (P<0,05) between mineral density of lumbar vertebrae L1-L4, left and right proximal femoral neck and total hip, distal forearm of not dominant arm and women body weight (rs from 0,36 to 0,54), body mass index (rs from 0,28 to 0,42), postmenopausal period duration (rs from -0,13 to -0,51). The osteoporosis at L1-L4 lumbar vertebrae had associations with GG genotype (Р=0,009) and G allele (Р=0,016) of VDR gene 283 A>G (BsmI) polymorphism. Correlation between 283 A>G (BsmI) polymorphism and osteoporotic changes in proximal femoral neck and total hip, distal forearm was not established (P>0,05). Conclusions: the obtained data can be used for detection of predisposition to osteoporosis development in postmenopausal women and treatment-and-prophylactic actions efficiency risings. |
| format | Article |
| id | doaj-art-c4765f86de1b4e96a8b80a6e52cb9a86 |
| institution | Matheson Library |
| issn | 2219-8075 2618-7876 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Медицинский вестник Юга России |
| spelling | doaj-art-c4765f86de1b4e96a8b80a6e52cb9a862025-07-03T16:13:38ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762016-12-0104323810.21886/2219-8075-2016-4-32-38363THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A>G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMENE. A. Maylyan0Donetsk National Medical University named after M. GorkyObjective: to study associations between VDR gene 283 A>G (BsmI) polymorphism and osteoporotic changes in various sites of skeleton in postmenopausal women. Materials and methods: 525 postmenopausal women were examined. The densitometry was carried out by dual energy X-ray absorptiometry. VDR gene 283 A>G (BsmI) polymorphism was investigated by the realtime PCR method. Results: this investigation determined correlation (P<0,05) between mineral density of lumbar vertebrae L1-L4, left and right proximal femoral neck and total hip, distal forearm of not dominant arm and women body weight (rs from 0,36 to 0,54), body mass index (rs from 0,28 to 0,42), postmenopausal period duration (rs from -0,13 to -0,51). The osteoporosis at L1-L4 lumbar vertebrae had associations with GG genotype (Р=0,009) and G allele (Р=0,016) of VDR gene 283 A>G (BsmI) polymorphism. Correlation between 283 A>G (BsmI) polymorphism and osteoporotic changes in proximal femoral neck and total hip, distal forearm was not established (P>0,05). Conclusions: the obtained data can be used for detection of predisposition to osteoporosis development in postmenopausal women and treatment-and-prophylactic actions efficiency risings.https://www.medicalherald.ru/jour/article/view/463vitamin the d receptor genepolymorphismbsmiwomenpostmenopauseosteoporosis |
| spellingShingle | E. A. Maylyan THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A>G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN Медицинский вестник Юга России vitamin the d receptor gene polymorphism bsmi women postmenopause osteoporosis |
| title | THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A>G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN |
| title_full | THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A>G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN |
| title_fullStr | THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A>G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN |
| title_full_unstemmed | THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A>G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN |
| title_short | THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A>G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN |
| title_sort | influence of vitamin d receptor gen 283 a g bsmi polymorphism on osteoporosis in postmenopausal women |
| topic | vitamin the d receptor gene polymorphism bsmi women postmenopause osteoporosis |
| url | https://www.medicalherald.ru/jour/article/view/463 |
| work_keys_str_mv | AT eamaylyan theinfluenceofvitamindreceptorgen283agbsmipolymorphismonosteoporosisinpostmenopausalwomen AT eamaylyan influenceofvitamindreceptorgen283agbsmipolymorphismonosteoporosisinpostmenopausalwomen |