Dual Redox Targeting by Pyrroloformamide A and Silver Ions Enhances Antibacterial and Anti-Biofilm Activity Against Carbapenem-Resistant <i>Klebsiella pneumoniae</i>

Dual Redox Targeting by Pyrroloformamide A and Silver Ions Enhances Antibacterial and Anti-Biofilm Activity Against Carbapenem-Resistant <i>Klebsiella pneumoniae</i>

<b>Background:</b> Dithiolopyrrolones (DTPs), such as holomycin and thiolutin, exhibit potent antibacterial activities. DTPs contain a disulfide within a unique bicyclic scaffold, which may chelate metal ions and disrupt metal-dependent cellular processes once the disulfide is reductivel...

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Bibliographic Details
Main Authors: Enhe Bai, Qingwen Tan, Xiong Yi, Jianghui Yao, Yanwen Duan, Yong Huang
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antibiotics
Subjects:
pyrroloformamide A
AgNO<sub>3</sub>
carbapenem-resistant <i>Klebsiella pneumoniae</i>
redox homeostasis
glutathione
thioredoxin
Online Access:https://www.mdpi.com/2079-6382/14/7/640
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