Impact of a Formulation Containing Chaga Extract, Coenzyme Q10, and Alpha-Lipoic Acid on Mitochondrial Dysfunction and Oxidative Stress: NMR Metabolomic Insights into Cellular Energy

QR Code

Impact of a Formulation Containing Chaga Extract, Coenzyme Q10, and Alpha-Lipoic Acid on Mitochondrial Dysfunction and Oxidative Stress: NMR Metabolomic Insights into Cellular Energy

Objectives: The aim of this study was to evaluate the impact of a novel antioxidant formulation (RE:PAIR, RP-25) containing CoQ10, alpha-lipoic acid, and Chaga extract on mitochondrial dysfunction and oxidative stress. To explore the activity of the formulation on neuronal cells, we explored cell me...

Full description

Saved in:

Bibliographic Details
Main Authors:	Maria D’Elia, Carmen Marino, Rita Celano, Enza Napolitano, Chiara Colarusso, Rosalinda Sorrentino, Anna Maria D’Ursi, Luca Rastrelli
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Antioxidants
Subjects:	coenzyme Q10 lipoic acid <i>Inonotus obliquus</i> SH-SY5Y cells UHPLC-HRMS/MS <sup>1</sup>H-NMR metabolomics
Online Access:	https://www.mdpi.com/2076-3921/14/6/753
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Integrating Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of <i>Inonotus obliquus</i> Polysaccharide in the Treatment of Rheumatoid Arthritis
by: Yuan Fu, et al.
Published: (2025-07-01)

Protective Activity of Aqueous Extracts from Higher Mushrooms Against Herpes sipmlex Virus Type-2 on Albino Mice Model
by: I. A. Razumov, et al.
Published: (2020-05-01)

Studying chemical signals in plant–soil mesofauna interactions
by: Bohm, Victoria, et al.
Published: (2024-01-01)

Adaptation of the sulfophosphovanillin method of analysis of total lipids for various biological objects as exemplified by <i>Drosophila melanogaster</i>
by: M. A. Eremina, et al.
Published: (2020-07-01)

<i>Rotavirus alphagastroenteritidis</i>: Circulating Strains After the Introduction of the Rotavirus Vaccine (Rotarix<sup>®</sup>) in Luanda Province of Angola
by: Dikudila G. Vita, et al.
Published: (2025-06-01)

Effects of <i>Yersinia pestis</i> Fra-Operon Carriage on the Cellular Morphologic Features of the Recipient <i>Yersinia pseudotuberculosis</i> Strain
by: A. A. Byvalov, et al.
Published: (2008-04-01)

Neurotoxic and Neuroprotective Effects of Psychedelics in a Human Neuroblastoma Cell Model
by: Andreia Machado Brito da Costa, et al.
Published: (2025-06-01)

Analysis of Novel DNA Adducts Derived from Acetaldehyde
by: Yuuki Betsuyaku, et al.
Published: (2025-06-01)

Metabolomics and lipidomics of plasma biomarkers for tuberculosis diagnostics using UHPLC-HRMS
by: Gaofeng Sun, et al.
Published: (2025-06-01)

CELL-MEDIATED IMMUNITY IN PATIENTS WITH POSTTRAUMATIC LONG BONE OSTEOMYELITIS IN THE COURSE OF MANAGEMENT WITH THE ILIZAROV METHOD
by: M. V. Chepeleva, et al.
Published: (2019-02-01)

Leaching Characteristics of Exogenous Cl<sup>−</sup> in Rain-Fed Potato Fields and Residual Estimation Model Validation
by: Jiaqi Li, et al.
Published: (2025-07-01)

Validation of a Real-Time PCR Assay for Fully Automated Detection of <i>Bacillus cereus</i> in Donor Human Milk
by: Gemma Aran, et al.
Published: (2025-07-01)

Radiolysis of Sub- and Supercritical Water Induced by <sup>10</sup>B(<i>n</i>,α)<sup>7</sup>Li Recoil Nuclei at 300–500 °C and 25 MPa
by: Md Shakhawat Hossen Bhuiyan, et al.
Published: (2025-06-01)

Triazine Calixarene as a Dual-Channel Chemosensor for the Reversible Detection of Cu<sup>2+</sup> and I<sup>−</sup> Ions via Water Content Modulation
by: Fuyong Wu, et al.
Published: (2025-06-01)

MelCher5k/<i>BRAF</i><sup>+</sup> subcutaneous human melanoma xenograft with CD20 expression
by: I. N. Mikhaylova, et al.
Published: (2025-06-01)

Severe Hereditary Hypofibrinogenemia in Pregnancy: A Case Report of a Novel Obstetrical Management with Thromboelastometry Guided Fibrinogen Supplementation
by: Grigorios Karampas, et al.
Published: (2025-06-01)

Establishing a 3D Spheroid Model of Cholinergic Neurons from SH-SY5Y Cells for Neurotoxicity Assessment
by: Felipe Franco-Campos, et al.
Published: (2025-07-01)

Characteristics of B-lymphocyte subpopulations in renal transplant recipients
by: S. V. Zybleva, et al.
Published: (2021-06-01)

Effect of Cooking and <i>in vitro</i> Digestion on the Polyphenols and Antioxidant Properties of <i>Asparagus officinalis</i> L. cultivars
by: Angela Di Matteo, et al.
Published: (2025-07-01)

Non-Targeted Lipidomics Analysis of Characteristic Milk Using High-Resolution Mass Spectrometry (UHPLC-HRMS)
by: Tingting Wei, et al.
Published: (2025-06-01)

Breeding and Ontogeny of the Aquarium-Traded Scissortail Rasbora (<i>Rasbora trilineata</i>)
by: Krittima Kasamawut, et al.
Published: (2025-06-01)

<i>IGFBP5</i> Promotes Atherosclerosis in APOE<sup>−/−</sup> Mice Through Phenotypic Transformation of VSMCs
by: Aoqi Xiang, et al.
Published: (2025-07-01)

Unified Underwater Communication Positioning Navigation and Timing Network System Design and Application
by: Lipeng Huo, et al.
Published: (2025-05-01)

Foliar Application of a Mixture of Amino Acid-Based Growth Promoters Enhances Tomato Seedling Production
by: Alexander Calero Hurtado, et al.
Published: (2025-05-01)

Mitochondrial DNA tRNA<sup>Leu</sup> and tRNA<sup>Ser</sup> polymorphism in different pig breeds
by: M. A. Kolosova, et al.
Published: (2018-10-01)

Societies large and small: On the rhetoric of the Third Section under Nicholas I
by: S. M. Voloshina
Published: (2023-03-01)

<sup>1</sup>H HRMAS NMR Metabolomics for the Characterization and Monitoring of Ripening in Pressed-Curd Ewe’s Milk Cheeses Produced Through Enzymatic Coagulation
by: David Castejón, et al.
Published: (2025-07-01)

Universal extremum of hyperplanes in some optimization problems
by: N. P. Fedotova
Published: (2010-09-01)

Evaluation of Timber Mechanical Properties Through Non-Destructive Testing: A Bibliometric Analysis
by: Marwa Brougui, et al.
Published: (2025-06-01)

Content of Short-Lived Radionuclides (<sup>95</sup>Zr, <sup>95</sup>Nb, <sup>103</sup>Ru, and <sup>106</sup>Ru) in Fish
by: Nataliia E. Zarubina, et al.
Published: (2025-07-01)

Differential Effects of Non-Microbial Biostimulants on Secondary Metabolites and Nitrate Content in Organic Arugula Leaves
by: Michele Ciriello, et al.
Published: (2025-07-01)

Different <sup>212</sup>Pb Generators and Its Radiation Safety Concerning <sup>220</sup>Rn (Thoron) Emanation
by: Marc Pretze, et al.
Published: (2025-05-01)

Dynamics of subpopulations of CD15<sup>+</sup>CD66b<sup>+</sup> and CD62L<sup>+</sup>CD63<sup>+</sup> circulating neutrophils in patients with benign neoplasms and progression of kidney cancer
by: I. R. Myagdieva, et al.
Published: (2025-06-01)

Poultry Mites Contributing to Human Dermatitis: A Retrospective Study in Italy (2010–2024)
by: Iolanda Moretta, et al.
Published: (2025-05-01)

Genome-Wide Identification and Expression Analysis of the <i>Shaker</i> K<sup>+</sup> Channel Gene Family in Cassava (<i>Manihot esculenta</i> Crantz) Under Potassium Stress
by: Xianhai Xie, et al.
Published: (2025-07-01)

<i>PPARgamma</i> Modulates CD4<sup>+</sup> T-Cell Differentiation and Allergic Inflammation in Allergic Rhinitis: A Potential Therapeutic Target
by: Xiaoqing Rui, et al.
Published: (2025-07-01)

Optimizing Stereotactic Intracranial Neoplasm Treatment: A Systematic Review of PET Integration with Gamma Knife Radiosurgery
by: Robert C. Subtirelu, et al.
Published: (2025-07-01)

Inonotus obliquus polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance
by: Yi-Fang Chen, et al.
Published: (2019-12-01)

Effects of low salinity stress on Na<sup>+</sup>-K<sup>+</sup>-ATPase activities, expression of Na<sup>+</sup>-K<sup>+</sup>-ATPase β-subunit mRNA and microscopical structure in gill filaments of juvenile Mugil cephalus
by: Li Lei, et al.
Published: (2014-03-01)

Beyond boundaries: Neuroprotective effects of steroids and ecdysteroids in SH‐SY5Y cells ‐ A systematic review
by: Bizhar Ahmed Tayeb, et al.
Published: (2024-06-01)