Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score‐Matched Study of US National Database Analysis
ABSTRACT Introduction While gastrointestinal involvement is a common manifestation of systemic lupus erythematosus (SLE), the association between gastroparesis and SLE remains unclear. Methods We analyzed data from the National Inpatient Sample (NIS) database from 2016 to 2021. Patients with gastrop...
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Wiley
2025-07-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.70227 |
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| author | Noppachai Siranart Pannathorn Nakaphan Thanathip Suenghataiphorn Panisara Fangsaard Tanattida Phanthong Patavee Pajareya Somkiat Phutinart Pawaris Tirakunwichcha Suwit Paksin Pornnicha Sowalertrat Sakkarin Chirapongsathorn Kittithat Tantitanawat |
| author_facet | Noppachai Siranart Pannathorn Nakaphan Thanathip Suenghataiphorn Panisara Fangsaard Tanattida Phanthong Patavee Pajareya Somkiat Phutinart Pawaris Tirakunwichcha Suwit Paksin Pornnicha Sowalertrat Sakkarin Chirapongsathorn Kittithat Tantitanawat |
| author_sort | Noppachai Siranart |
| collection | DOAJ |
| description | ABSTRACT Introduction While gastrointestinal involvement is a common manifestation of systemic lupus erythematosus (SLE), the association between gastroparesis and SLE remains unclear. Methods We analyzed data from the National Inpatient Sample (NIS) database from 2016 to 2021. Patients with gastroparesis were categorized into SLE and non‐SLE groups. Similarly, patients with SLE were categorized into gastroparesis and nongastroparesis groups. Clinical characteristics, comorbidities, hospitalization data, and outcomes were compared. The primary outcome was the association between SLE and primary gastroparesis. Secondary outcomes were clinical impacts of gastroparesis in patients with or without SLE. Results A total of 12 538 228 patients were included from the NIS database. Of these, 1 165 925 patients (9.3%) were diagnosed with gastroparesis during hospitalization, while 11 372 303 patients (90.7%) did not have gastroparesis. SLE was significantly more common in patients with gastroparesis compared to those without (1.6% vs. 0.7%, p < 0.001; aOR 1.87 [95% CI: 1.80–1.95]). Among patients hospitalized with gastroparesis, those with SLE had a longer length of stay, with a β‐coefficient of 0.31 (95% CI: 0.07–0.55, p = 0.009), lower hospitalization charges, with mean differences of $4761 (95% CI: 442–9080, p = 0.031), and a higher rate of intervention needs, with odds ratios of 1.31 (95% CI: 1.09–1.56, p = 0.003). After propensity‐score matching (1:1), SLE patients aged ≥ 65 had higher hospital charges, with mean differences of $7287 (95% CI: 2928–11 646, p = 0.01), compared to non‐SLE patients. Conclusion Gastroparesis is associated with SLE, contributing to longer hospitalizations, higher costs, and increased need for invasive interventions. These findings underscore the importance of evaluating gastroparesis in SLE patients to enable early management and reduce potential complications. |
| format | Article |
| id | doaj-art-c31c74b3a283470a8a89fcf430714ae2 |
| institution | Matheson Library |
| issn | 2397-9070 |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-c31c74b3a283470a8a89fcf430714ae22025-07-25T07:26:40ZengWileyJGH Open2397-90702025-07-0197n/an/a10.1002/jgh3.70227Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score‐Matched Study of US National Database AnalysisNoppachai Siranart0Pannathorn Nakaphan1Thanathip Suenghataiphorn2Panisara Fangsaard3Tanattida Phanthong4Patavee Pajareya5Somkiat Phutinart6Pawaris Tirakunwichcha7Suwit Paksin8Pornnicha Sowalertrat9Sakkarin Chirapongsathorn10Kittithat Tantitanawat11Division of Gastroenterology Hepatology and Endoscopy, Brigham and Women's Hospital Boston Massachusetts USADepartment of Internal Medicine Weiss Memorial Hospital Chicago Illinois USADepartment of Medicine Griffin Hospital Derby Connecticut USADepartment of Internal Medicine Bassett Medical Center Cooperstown New York USAFaculty of Medicine King Chulalongkorn Memorial Hospital Bangkok ThailandFaculty of Medicine King Chulalongkorn Memorial Hospital Bangkok ThailandFaculty of Medicine King Chulalongkorn Memorial Hospital Bangkok ThailandFaculty of Medicine King Chulalongkorn Memorial Hospital Bangkok ThailandFaculty of Medicine King Chulalongkorn Memorial Hospital Bangkok ThailandFaculty of Medicine Srinakharinwirot University Bangkok ThailandDivision of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital and College of Medicine Bangkok ThailandDivision of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital and College of Medicine Bangkok ThailandABSTRACT Introduction While gastrointestinal involvement is a common manifestation of systemic lupus erythematosus (SLE), the association between gastroparesis and SLE remains unclear. Methods We analyzed data from the National Inpatient Sample (NIS) database from 2016 to 2021. Patients with gastroparesis were categorized into SLE and non‐SLE groups. Similarly, patients with SLE were categorized into gastroparesis and nongastroparesis groups. Clinical characteristics, comorbidities, hospitalization data, and outcomes were compared. The primary outcome was the association between SLE and primary gastroparesis. Secondary outcomes were clinical impacts of gastroparesis in patients with or without SLE. Results A total of 12 538 228 patients were included from the NIS database. Of these, 1 165 925 patients (9.3%) were diagnosed with gastroparesis during hospitalization, while 11 372 303 patients (90.7%) did not have gastroparesis. SLE was significantly more common in patients with gastroparesis compared to those without (1.6% vs. 0.7%, p < 0.001; aOR 1.87 [95% CI: 1.80–1.95]). Among patients hospitalized with gastroparesis, those with SLE had a longer length of stay, with a β‐coefficient of 0.31 (95% CI: 0.07–0.55, p = 0.009), lower hospitalization charges, with mean differences of $4761 (95% CI: 442–9080, p = 0.031), and a higher rate of intervention needs, with odds ratios of 1.31 (95% CI: 1.09–1.56, p = 0.003). After propensity‐score matching (1:1), SLE patients aged ≥ 65 had higher hospital charges, with mean differences of $7287 (95% CI: 2928–11 646, p = 0.01), compared to non‐SLE patients. Conclusion Gastroparesis is associated with SLE, contributing to longer hospitalizations, higher costs, and increased need for invasive interventions. These findings underscore the importance of evaluating gastroparesis in SLE patients to enable early management and reduce potential complications.https://doi.org/10.1002/jgh3.70227gastroparesisSLEsystemic lupus erythematosus |
| spellingShingle | Noppachai Siranart Pannathorn Nakaphan Thanathip Suenghataiphorn Panisara Fangsaard Tanattida Phanthong Patavee Pajareya Somkiat Phutinart Pawaris Tirakunwichcha Suwit Paksin Pornnicha Sowalertrat Sakkarin Chirapongsathorn Kittithat Tantitanawat Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score‐Matched Study of US National Database Analysis JGH Open gastroparesis SLE systemic lupus erythematosus |
| title | Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score‐Matched Study of US National Database Analysis |
| title_full | Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score‐Matched Study of US National Database Analysis |
| title_fullStr | Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score‐Matched Study of US National Database Analysis |
| title_full_unstemmed | Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score‐Matched Study of US National Database Analysis |
| title_short | Gastroparesis and Systemic Lupus Erythematosus: A Propensity Score‐Matched Study of US National Database Analysis |
| title_sort | gastroparesis and systemic lupus erythematosus a propensity score matched study of us national database analysis |
| topic | gastroparesis SLE systemic lupus erythematosus |
| url | https://doi.org/10.1002/jgh3.70227 |
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