OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY
The solid-phase synthesis of a tetrameric model sequence of polyamide nucleic acid mimetics (PANAM) incorporating terminal chiral and charged unit was performed. As a result during the synthesis and cleavage from the resin the tendency of PANAM with the N-terminal negatively charged monomer to cycli...
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2013-02-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/659 |
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| author | M. V. Shirayeva Yu. G. Kirillova E. D. Nikol’Skaya D. I. Prokhorov I. P. Smirnov G. E. Pozmogova |
| author_facet | M. V. Shirayeva Yu. G. Kirillova E. D. Nikol’Skaya D. I. Prokhorov I. P. Smirnov G. E. Pozmogova |
| author_sort | M. V. Shirayeva |
| collection | DOAJ |
| description | The solid-phase synthesis of a tetrameric model sequence of polyamide nucleic acid mimetics (PANAM) incorporating terminal chiral and charged unit was performed. As a result during the synthesis and cleavage from the resin the tendency of PANAM with the N-terminal negatively charged monomer to cyclization with simultaneous N-acyl transfer of carboxyethyl base residue was found. Application of MALDI-TOF mass - spectrometry allowed us to find suitable conditions for obtaining PANAM oligomers without the significant amount of by-products. |
| format | Article |
| id | doaj-art-c2b7fce3f4114d9582bc4c27a07f13ad |
| institution | Matheson Library |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2013-02-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-c2b7fce3f4114d9582bc4c27a07f13ad2025-08-04T10:19:35ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752013-02-01818795653OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRYM. V. Shirayeva0Yu. G. Kirillova1E. D. Nikol’Skaya2D. I. Prokhorov3I. P. Smirnov4G. E. Pozmogova5M.V. Lomonosov Moscow State University of Fine Chemical TechnologyM.V. Lomonosov Moscow State University of Fine Chemical TechnologyM.V. Lomonosov Moscow State University of Fine Chemical TechnologyM.V. Lomonosov Moscow State University of Fine Chemical TechnologyScientific Research Institute of Physical and Chemical MedicineScientific Research Institute of Physical and Chemical MedicineThe solid-phase synthesis of a tetrameric model sequence of polyamide nucleic acid mimetics (PANAM) incorporating terminal chiral and charged unit was performed. As a result during the synthesis and cleavage from the resin the tendency of PANAM with the N-terminal negatively charged monomer to cyclization with simultaneous N-acyl transfer of carboxyethyl base residue was found. Application of MALDI-TOF mass - spectrometry allowed us to find suitable conditions for obtaining PANAM oligomers without the significant amount of by-products.https://www.finechem-mirea.ru/jour/article/view/659полиамидные миметики нуклеиновых кислотпептидно-нуклеиновые кислоты (пнк)твердофазный синтезmaldi-tof-масс-спектрометрияpolyamide nucleic acid mimetics (panam)peptide nucleic acids (pna)solid phase synthesismaldi-tof mass-spectrometry |
| spellingShingle | M. V. Shirayeva Yu. G. Kirillova E. D. Nikol’Skaya D. I. Prokhorov I. P. Smirnov G. E. Pozmogova OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY Тонкие химические технологии полиамидные миметики нуклеиновых кислот пептидно-нуклеиновые кислоты (пнк) твердофазный синтез maldi-tof-масс-спектрометрия polyamide nucleic acid mimetics (panam) peptide nucleic acids (pna) solid phase synthesis maldi-tof mass-spectrometry |
| title | OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY |
| title_full | OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY |
| title_fullStr | OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY |
| title_full_unstemmed | OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY |
| title_short | OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY |
| title_sort | optimization of solid phase synthesis of polyamide nucleic acid mimetics with application of maldi tof mass spectrometry |
| topic | полиамидные миметики нуклеиновых кислот пептидно-нуклеиновые кислоты (пнк) твердофазный синтез maldi-tof-масс-спектрометрия polyamide nucleic acid mimetics (panam) peptide nucleic acids (pna) solid phase synthesis maldi-tof mass-spectrometry |
| url | https://www.finechem-mirea.ru/jour/article/view/659 |
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