Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration
<b>Background/Objectives</b>: Degenerative spinal conditions, such as degenerative stenosis, have been linked to metabolic and lifestyle factors, including obesity, smoking, and diabetes. Glial cell line-derived neurotrophic factor (GDNF) plays a crucial role in neuroprotection, but its...
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MDPI AG
2025-06-01
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| author | Dawid Sobański Małgorzata Sobańska Rafał Staszkiewicz Damian Strojny Werner Dammermann Paweł Gogol Weronika Wieczorek-Olcha Artur Chwalba Beniamin Oskar Grabarek |
| author_facet | Dawid Sobański Małgorzata Sobańska Rafał Staszkiewicz Damian Strojny Werner Dammermann Paweł Gogol Weronika Wieczorek-Olcha Artur Chwalba Beniamin Oskar Grabarek |
| author_sort | Dawid Sobański |
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| description | <b>Background/Objectives</b>: Degenerative spinal conditions, such as degenerative stenosis, have been linked to metabolic and lifestyle factors, including obesity, smoking, and diabetes. Glial cell line-derived neurotrophic factor (GDNF) plays a crucial role in neuroprotection, but its relationship with these risk factors remains unclear. <b>Methods</b>: This study aims to evaluate the relationship between body mass index (BMI), smoking, diabetes, and GDNF levels in patients with degenerative spine conditions. We measured the GDNF levels in patients with degenerative stenosis and assessed the impact of BMI, smoking status, and the presence of diabetes. Comparisons were made using appropriate statistical analyses to determine the significance of these factors on GDNF levels. <b>Results</b>: A significant inverse relationship was observed between the BMI and GDNF levels (<i>p</i> < 0.01). Patients with a higher BMI exhibited lower GDNF concentrations. Additionally, patients who smoked or had diabetes showed significantly lower GDNF levels compared to non-smokers and those without diabetes (<i>p</i> = 0.03 and <i>p</i> = 0.02, respectively). These findings suggest that both metabolic and lifestyle factors are associated with decreased GDNF, which may accelerate neurodegenerative processes in the spine. <b>Conclusions</b>: Our study demonstrates that increased BMI, smoking, and diabetes are linked to reduced GDNF levels, potentially contributing to the progression of degenerative spine conditions such as stenosis. These findings highlight the need for targeted clinical interventions to manage these risk factors, aiming to preserve GDNF levels and slow the degenerative processes in the spine. Future research should explore therapeutic approaches to modulate GDNF in affected populations. |
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| language | English |
| publishDate | 2025-06-01 |
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| series | Biomedicines |
| spelling | doaj-art-c27d3b90d4b044b3bcf4ceeca3bfd8d32025-07-25T13:15:27ZengMDPI AGBiomedicines2227-90592025-06-01137153010.3390/biomedicines13071530Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum DegenerationDawid Sobański0Małgorzata Sobańska1Rafał Staszkiewicz2Damian Strojny3Werner Dammermann4Paweł Gogol5Weronika Wieczorek-Olcha6Artur Chwalba7Beniamin Oskar Grabarek8Department of Neurosurgery, Szpital sw. Rafala in Cracow, 30-693 Cracow, PolandDepartment of Neurosurgery, Szpital sw. Rafala in Cracow, 30-693 Cracow, PolandCollegium Medicum, WSB University, 41-300 Dabrowa Gornicza, PolandCollegium Medicum, WSB University, 41-300 Dabrowa Gornicza, PolandCenter of Internal Medicine II, University Hospital Brandenburg, 03048 Brandenburg, GermanyCollegium Medicum, WSB University, 41-300 Dabrowa Gornicza, PolandCollegium Medicum, WSB University, 41-300 Dabrowa Gornicza, PolandGeneral Rehabilitation Sub-Department, Edmund Wojtyla Małopolski Hospital for Lung Diseases and
Rehabilitation, 32-310 Jaroszowiec, PolandCollegium Medicum, WSB University, 41-300 Dabrowa Gornicza, Poland<b>Background/Objectives</b>: Degenerative spinal conditions, such as degenerative stenosis, have been linked to metabolic and lifestyle factors, including obesity, smoking, and diabetes. Glial cell line-derived neurotrophic factor (GDNF) plays a crucial role in neuroprotection, but its relationship with these risk factors remains unclear. <b>Methods</b>: This study aims to evaluate the relationship between body mass index (BMI), smoking, diabetes, and GDNF levels in patients with degenerative spine conditions. We measured the GDNF levels in patients with degenerative stenosis and assessed the impact of BMI, smoking status, and the presence of diabetes. Comparisons were made using appropriate statistical analyses to determine the significance of these factors on GDNF levels. <b>Results</b>: A significant inverse relationship was observed between the BMI and GDNF levels (<i>p</i> < 0.01). Patients with a higher BMI exhibited lower GDNF concentrations. Additionally, patients who smoked or had diabetes showed significantly lower GDNF levels compared to non-smokers and those without diabetes (<i>p</i> = 0.03 and <i>p</i> = 0.02, respectively). These findings suggest that both metabolic and lifestyle factors are associated with decreased GDNF, which may accelerate neurodegenerative processes in the spine. <b>Conclusions</b>: Our study demonstrates that increased BMI, smoking, and diabetes are linked to reduced GDNF levels, potentially contributing to the progression of degenerative spine conditions such as stenosis. These findings highlight the need for targeted clinical interventions to manage these risk factors, aiming to preserve GDNF levels and slow the degenerative processes in the spine. Future research should explore therapeutic approaches to modulate GDNF in affected populations.https://www.mdpi.com/2227-9059/13/7/1530glial cell line-derived neurotrophic factor (GDNF)degenerative stenosishabits |
| spellingShingle | Dawid Sobański Małgorzata Sobańska Rafał Staszkiewicz Damian Strojny Werner Dammermann Paweł Gogol Weronika Wieczorek-Olcha Artur Chwalba Beniamin Oskar Grabarek Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration Biomedicines glial cell line-derived neurotrophic factor (GDNF) degenerative stenosis habits |
| title | Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration |
| title_full | Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration |
| title_fullStr | Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration |
| title_full_unstemmed | Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration |
| title_short | Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration |
| title_sort | lifestyle and clinical predictors of glial cell line derived neurotrophic factor expression in lumbosacral stenosis related ligamentum flavum degeneration |
| topic | glial cell line-derived neurotrophic factor (GDNF) degenerative stenosis habits |
| url | https://www.mdpi.com/2227-9059/13/7/1530 |
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