Salutary Effects of Overexpression of Rsm22, an Assembly Factor for the Mitochondrial Ribosome, on Frataxin/Yfh1 Depletion Phenotypes in <i>Saccharomyces cerevisiae</i>

Salutary Effects of Overexpression of Rsm22, an Assembly Factor for the Mitochondrial Ribosome, on Frataxin/Yfh1 Depletion Phenotypes in <i>Saccharomyces cerevisiae</i>

Frataxin is a component of the iron–sulfur (Fe-S) cluster assembly complex in mitochondria, and deficiency is associated with Friedreich ataxia (FA). The yeast homolog Yfh1 resembles and cross-complements with its human equivalent, and frataxin bypass scenarios are of particular interest because the...

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Bibliographic Details
Main Authors: Ashutosh K. Pandey, Pratibha Singh, Jayashree Pain, Andrew Dancis, Debkumar Pain
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
yeast
mitochondria
frataxin
Yfh1
ferredoxin
iron–sulfur proteins
Online Access:https://www.mdpi.com/2218-273X/15/6/785
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