Glymphatic dysfunction is related to motor disability fully mediated by gray matter degeneration in early-stage Parkinson's disease

Glymphatic dysfunction is related to motor disability fully mediated by gray matter degeneration in early-stage Parkinson's disease

Background: Glymphatic dysfunction plays a critical role in Parkinson's disease (PD), but its impact on neurodegeneration and clinical symptoms in the early-stage remains unclear. This study investigates the relationship between glymphatic dysfunction, gray matter (GM) degeneration, and clinica...

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Main Authors: Zihao Zhu, Xiaojie Duanmu, Cheng Zhou, Jiaqi Wen, Jianmei Qin, Qianshi Zheng, Weijin Yuan, Tao Guo, Haoting Wu, Chenqing Wu, Jingwen Chen, Jingjing Wu, Yingni Jin, Nan Lu, Lu Wang, Bingting Zhu, Yuelin Fang, Lifang Wang, Ziyi Zhu, Yaping Yan, Baorong Zhang, Minming Zhang, Xiaojun Guan, Xiaojun Xu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Glymphatic system
DTI-ALPS index
Mediation analysis
Disease progression
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002177
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