Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy
Aim: to describe non-spesific and specific immune response profile in Indonesian thalassemia major with and without splenectomy. Methods: this study was held at Thalassaemia Centre, Cipto Mangunkusumo Hospital Jakarta on September 2013 – February 2014. A comparative cross sectional study was conduc...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2016-05-01
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| Series: | Acta Medica Indonesiana |
| Online Access: | https://www.actamedindones.org/index.php/ijim/article/view/91 |
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| author | Teny T Sari1 Djajadiman Gatot Arwin A.P. Akib Saptawati Bardosono Sri R.S. Hadinegoro Alida R Harahap Ponpon S Idjradinata |
| author_facet | Teny T Sari1 Djajadiman Gatot Arwin A.P. Akib Saptawati Bardosono Sri R.S. Hadinegoro Alida R Harahap Ponpon S Idjradinata |
| author_sort | Teny T Sari1 |
| collection | DOAJ |
| description |
Aim: to describe non-spesific and specific immune response profile in Indonesian thalassemia major with and without splenectomy. Methods: this study was held at Thalassaemia Centre, Cipto Mangunkusumo Hospital Jakarta on September 2013 – February 2014. A comparative cross sectional study was conducted in healthy, thalassemia major aged more than 12 year and seronegative HIV. They were matched in age and sex for splenectomised and non-splenectomised groups, analysing the non-spesific immune response (neutrophil count and phagocytosis) and specific immune response (count and function of cellular immunity). Infection episodes were also analized as immune response in vivo parameter. Results: splenectomised thalassemia major showed increased neutrophil count but significantly decreased non-spesific immune response (neutrophil phagocytosis). Spesific immune response of splenectomised group presented significantly higher absolute lymphocyte, lymphocyte T, CD4+ and CD8+ counts compared to non-splenectomised thalassemia major (p<0.05). Ratio CD4+/CD8+ were similar in these groups. Serum marker of activated cellular imunity function (IL-2 and TNF-α) were similar among two groups. Mild infection episodes on splenectomised and non-splenectomised group were 2.02 (ranged 0 to 12) times and 0.81 (ranged 0 to 8) times (p=0.004), respectively. Severe infection on splenectomised group were sepsis for 2 weeks and diarrhea for 1 week, whereas on non-splenectomised group was typhoid fever for 4 days. Conclusion: there were significant differences on immune response among thalassemia major patients. Splenectomised thalassemia major showed a greater degree of susceptibility to infections than non-splenectomised thalassemia major.
Key words: immune response, thalassemia major, splenectomy.
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| format | Article |
| id | doaj-art-c1efafb6c29c44f29a77514a35b781d7 |
| institution | Matheson Library |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-c1efafb6c29c44f29a77514a35b781d72025-07-23T07:03:01ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322016-05-01463Immune Response of Thalassemia Major Patients in Indonesia with and without SplenectomyTeny T Sari10Djajadiman Gatot1Arwin A.P. Akib2Saptawati Bardosono3Sri R.S. Hadinegoro4Alida R Harahap5Ponpon S Idjradinata6Department of Pediatrics, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Pediatrics, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Pediatrics, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Clinical Nutrition, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital Jakarta, IndonesiaDepartment of Pediatrics, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital Jakarta, IndonesiaDepartment of Child Health, Faculty of Medicine, Universitas Padjajaran - Hasan Sadikin Hospital, Bandung, Indonesia Aim: to describe non-spesific and specific immune response profile in Indonesian thalassemia major with and without splenectomy. Methods: this study was held at Thalassaemia Centre, Cipto Mangunkusumo Hospital Jakarta on September 2013 – February 2014. A comparative cross sectional study was conducted in healthy, thalassemia major aged more than 12 year and seronegative HIV. They were matched in age and sex for splenectomised and non-splenectomised groups, analysing the non-spesific immune response (neutrophil count and phagocytosis) and specific immune response (count and function of cellular immunity). Infection episodes were also analized as immune response in vivo parameter. Results: splenectomised thalassemia major showed increased neutrophil count but significantly decreased non-spesific immune response (neutrophil phagocytosis). Spesific immune response of splenectomised group presented significantly higher absolute lymphocyte, lymphocyte T, CD4+ and CD8+ counts compared to non-splenectomised thalassemia major (p<0.05). Ratio CD4+/CD8+ were similar in these groups. Serum marker of activated cellular imunity function (IL-2 and TNF-α) were similar among two groups. Mild infection episodes on splenectomised and non-splenectomised group were 2.02 (ranged 0 to 12) times and 0.81 (ranged 0 to 8) times (p=0.004), respectively. Severe infection on splenectomised group were sepsis for 2 weeks and diarrhea for 1 week, whereas on non-splenectomised group was typhoid fever for 4 days. Conclusion: there were significant differences on immune response among thalassemia major patients. Splenectomised thalassemia major showed a greater degree of susceptibility to infections than non-splenectomised thalassemia major. Key words: immune response, thalassemia major, splenectomy. https://www.actamedindones.org/index.php/ijim/article/view/91 |
| spellingShingle | Teny T Sari1 Djajadiman Gatot Arwin A.P. Akib Saptawati Bardosono Sri R.S. Hadinegoro Alida R Harahap Ponpon S Idjradinata Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy Acta Medica Indonesiana |
| title | Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy |
| title_full | Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy |
| title_fullStr | Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy |
| title_full_unstemmed | Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy |
| title_short | Immune Response of Thalassemia Major Patients in Indonesia with and without Splenectomy |
| title_sort | immune response of thalassemia major patients in indonesia with and without splenectomy |
| url | https://www.actamedindones.org/index.php/ijim/article/view/91 |
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