Effect of smoking cessation on new-onset diabetes mellitus in dyslipidemic individuals: A population-based cohort study
Introduction Smoking is a modifiable risk factor for diabetes mellitus, but the association between changes in smoking behavior and new-onset diabetes mellitus (NODM) in dyslipidemic patients remains unclear. This study aimed to examine how changes in smoking habits affect NODM risk among individual...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2025-06-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | https://www.tobaccoinduceddiseases.org/Effect-of-smoking-cessation-on-new-onset-diabetes-mellitus-in-dyslipidemic-individuals,205418,0,2.html |
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| Summary: | Introduction
Smoking is a modifiable risk factor for diabetes mellitus, but the
association between changes in smoking behavior and new-onset diabetes
mellitus (NODM) in dyslipidemic patients remains unclear. This study aimed to
examine how changes in smoking habits affect NODM risk among individuals
with dyslipidemia.
Methods
This retrospective cohort study used data from the Korean National
Health Insurance Service–National Sample Cohort (NHIS–NSC). A total of 34282
patients diagnosed with dyslipidemia between 2012 and 2014 were followed
until December 2019 (median follow-up: 5 years). Smoking behavior change
was defined by transitions in smoking status and intensity across two health
examinations. NODM was identified by fasting plasma glucose ≥126 mg/dL or
ICD-10 codes E11–E14 with antidiabetic medication.
Results
During follow-up, 2479 participants (7.23%) developed NODM. Those
with NODM had higher prevalence of obesity, abdominal obesity, hypertension,
abnormal liver function, and family history of diabetes. Current smokers had
increased NODM risk (hazard ratio, HR=1.36; 95% CI: 1.22–1.50) versus nonsmokers.
Heavy smokers had higher risk (HR=1.43; 95% CI: 1.24–1.60) than
moderate smokers (HR=1.35; 95% CI: 1.16–1.60). Compared to continuous
smokers, quitters had reduced risk (HR=0.79; 95% CI: 0.64–0.98), while reducers
showed no significant risk reduction (HR=0.82; 95% CI: 0.63–1.08).
Conclusions
Among patients with dyslipidemia, smoking cessation was associated
with a lower risk of NODM compared to continued smoking. These results suggest
potential benefits of quitting smoking in reducing diabetes risk in this population. |
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| ISSN: | 1617-9625 |