Biophysiological and biochemical parameters among patients with hypertension- A cross-sectional study
Background: Research evidence highlights modifiable risk factors as key elements in preventing hypertension and its complications. This study explores their association with hypertension to inform preventive strategies. Objectives: We assessed the socio-clinical, bio-physiological, and biochemical p...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Clinical Epidemiology and Global Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213398425001915 |
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| author | Betcy George Porkodi Arjunan Abraham M. Ittyachen M. Rajkumar N.A. Sheela Shenai Soney Meleth Varghese Ramesh Chandrababu |
| author_facet | Betcy George Porkodi Arjunan Abraham M. Ittyachen M. Rajkumar N.A. Sheela Shenai Soney Meleth Varghese Ramesh Chandrababu |
| author_sort | Betcy George |
| collection | DOAJ |
| description | Background: Research evidence highlights modifiable risk factors as key elements in preventing hypertension and its complications. This study explores their association with hypertension to inform preventive strategies. Objectives: We assessed the socio-clinical, bio-physiological, and biochemical parameters and its associated factors. Materials and methods: This hospital-based cross-sectional study involved 220 hypertensive patients. The outcome variables were assessed using biophysiological and biochemical methods.Association between socio-clinical variables with bio-physiological and biochemical parameters was done with the Mann-Whitney U test, ANOVA, Kruskal-Wallis ANOVA, and Spearman's correlation. p < 0.05 was considered statistically significant. Results: 71.36 % had hypertension for the past 10 years, 73.63 % were on anti-hypertensives for 10 years, and 80.91 % were prescribed a single drug. The median HDL and LDL levels were 58 mg/dL and 140 mg/dL, respectively.Weight emerged as a strong positive contributor to all three BP measures [systolic blood pressure (SBP): p = 0.026, diastolic blood pressure (DBP): p = 0.001, and mean arterial pressure (MAP): p = 0.001], highlighting its potential role in BP control. Gender disparities were evident, with men having higher DBP (p < 0.001) and MAP (p = 0.003) compared to women. Smoking habit was particularly detrimental, showing a significant association with higher DBP (p = 0.016). A link between heart rate and comorbid conditions (p = 0.044) suggests a potential interplay between weight, hypertension, and overall health. Linear regression analysis revealed a statistically significant positive association between weight, DBP, and MAP (p < 0.05 for both). Conclusions: Age showed a weak correlation, and weight management emerged as a crucial factor for BP control. Strategies to decrease weight would be crucial for the control of hypertension. |
| format | Article |
| id | doaj-art-c16f8b9d5fb144b4a0b5fb6ebdf18067 |
| institution | Matheson Library |
| issn | 2213-3984 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Epidemiology and Global Health |
| spelling | doaj-art-c16f8b9d5fb144b4a0b5fb6ebdf180672025-07-26T05:23:15ZengElsevierClinical Epidemiology and Global Health2213-39842025-07-0134102102Biophysiological and biochemical parameters among patients with hypertension- A cross-sectional studyBetcy George0Porkodi Arjunan1Abraham M. Ittyachen2M. Rajkumar3N.A. Sheela Shenai4Soney Meleth Varghese5Ramesh Chandrababu6Sri Ramachandra Faculty of Nursing, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, Tamil Nadu, India; M.O.S.C. College of Nursing, Kolenchery, Kerala, IndiaDepartment of Nursing, College of Applied Medical Sciences, King Faisal University, Saudi ArabiaDepartment of Medicine, Malankara Orthodox Syrian Church Medical College and Hospital, Ernakulam District, Kolenchery, Kerala, IndiaDepartment of General Medicine, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, Tamil Nadu, IndiaM.O.S.C. College of Nursing, Kolenchery, Kerala, IndiaDepartment of Community Health Nursing, College of Nursing Sciences, Gulf Medical University, Ajman, United Arab EmiratesDepartment of Medical-Surgical Nursing, Sri Ramachandra Faculty of Nursing, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, Tamil Nadu, India; Corresponding author.Background: Research evidence highlights modifiable risk factors as key elements in preventing hypertension and its complications. This study explores their association with hypertension to inform preventive strategies. Objectives: We assessed the socio-clinical, bio-physiological, and biochemical parameters and its associated factors. Materials and methods: This hospital-based cross-sectional study involved 220 hypertensive patients. The outcome variables were assessed using biophysiological and biochemical methods.Association between socio-clinical variables with bio-physiological and biochemical parameters was done with the Mann-Whitney U test, ANOVA, Kruskal-Wallis ANOVA, and Spearman's correlation. p < 0.05 was considered statistically significant. Results: 71.36 % had hypertension for the past 10 years, 73.63 % were on anti-hypertensives for 10 years, and 80.91 % were prescribed a single drug. The median HDL and LDL levels were 58 mg/dL and 140 mg/dL, respectively.Weight emerged as a strong positive contributor to all three BP measures [systolic blood pressure (SBP): p = 0.026, diastolic blood pressure (DBP): p = 0.001, and mean arterial pressure (MAP): p = 0.001], highlighting its potential role in BP control. Gender disparities were evident, with men having higher DBP (p < 0.001) and MAP (p = 0.003) compared to women. Smoking habit was particularly detrimental, showing a significant association with higher DBP (p = 0.016). A link between heart rate and comorbid conditions (p = 0.044) suggests a potential interplay between weight, hypertension, and overall health. Linear regression analysis revealed a statistically significant positive association between weight, DBP, and MAP (p < 0.05 for both). Conclusions: Age showed a weak correlation, and weight management emerged as a crucial factor for BP control. Strategies to decrease weight would be crucial for the control of hypertension.http://www.sciencedirect.com/science/article/pii/S2213398425001915Bio-physiological parametersBiochemical parametersCardiovascular riskHigh blood pressureHypertension |
| spellingShingle | Betcy George Porkodi Arjunan Abraham M. Ittyachen M. Rajkumar N.A. Sheela Shenai Soney Meleth Varghese Ramesh Chandrababu Biophysiological and biochemical parameters among patients with hypertension- A cross-sectional study Clinical Epidemiology and Global Health Bio-physiological parameters Biochemical parameters Cardiovascular risk High blood pressure Hypertension |
| title | Biophysiological and biochemical parameters among patients with hypertension- A cross-sectional study |
| title_full | Biophysiological and biochemical parameters among patients with hypertension- A cross-sectional study |
| title_fullStr | Biophysiological and biochemical parameters among patients with hypertension- A cross-sectional study |
| title_full_unstemmed | Biophysiological and biochemical parameters among patients with hypertension- A cross-sectional study |
| title_short | Biophysiological and biochemical parameters among patients with hypertension- A cross-sectional study |
| title_sort | biophysiological and biochemical parameters among patients with hypertension a cross sectional study |
| topic | Bio-physiological parameters Biochemical parameters Cardiovascular risk High blood pressure Hypertension |
| url | http://www.sciencedirect.com/science/article/pii/S2213398425001915 |
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