Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degeneration
Purpose: We aim to evaluate the changes in the size of drusens and drusenoid pigment epithelial detachments (PED) in patients with age-related macular degeneration. Design: This study was designed as an observational retrospective cohort study. Methods: We evaluated eyes with drusenoid PED tracked u...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_1966_24 |
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| author | Sinem Karabulut Sema Tamer Kaderli Aylin Karalezli |
| author_facet | Sinem Karabulut Sema Tamer Kaderli Aylin Karalezli |
| author_sort | Sinem Karabulut |
| collection | DOAJ |
| description | Purpose:
We aim to evaluate the changes in the size of drusens and drusenoid pigment epithelial detachments (PED) in patients with age-related macular degeneration.
Design:
This study was designed as an observational retrospective cohort study.
Methods:
We evaluated eyes with drusenoid PED tracked using spectral-domain and enhanced depth imaging optical coherence tomography. The cases were classified according to the follow-up visits and divided into two groups as eyes with collapsed PED and persisting PED. The best-corrected visual acuity (BCVA), size of drusens and PED, central macular thickness (CMT), and subfoveal choroidal thickness (SCT) were recorded.
Results:
We included 11 patients’ 22 eyes with drusenoid PED. In the final comparison, the mean CMT, SCT, and BCVA were significantly lower in Group 1 compared to Group 2 (P = 0.05; P = 0.05; P = 0.002, respectively). The mean CMT, SCT, and BCVA were significantly decreased from baseline to the last visit in Group 1 (P = 0.013; P < 0.001; P = 0.001, respectively). No significant changes were observed regarding the mean CMT, SCT, and BCVA in Group 2 during the follow-up visits. (P = 0.317, P = 0.682, P = 0.056).
Conclusion:
Spontaneous collapse of drusenoid PED is associated with poor visual outcome. |
| format | Article |
| id | doaj-art-c13d7cede43f41d08087bf2ba68e2fd6 |
| institution | Matheson Library |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-c13d7cede43f41d08087bf2ba68e2fd62025-07-04T07:45:15ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-06-0173684384610.4103/IJO.IJO_1966_24Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degenerationSinem KarabulutSema Tamer KaderliAylin KaralezliPurpose: We aim to evaluate the changes in the size of drusens and drusenoid pigment epithelial detachments (PED) in patients with age-related macular degeneration. Design: This study was designed as an observational retrospective cohort study. Methods: We evaluated eyes with drusenoid PED tracked using spectral-domain and enhanced depth imaging optical coherence tomography. The cases were classified according to the follow-up visits and divided into two groups as eyes with collapsed PED and persisting PED. The best-corrected visual acuity (BCVA), size of drusens and PED, central macular thickness (CMT), and subfoveal choroidal thickness (SCT) were recorded. Results: We included 11 patients’ 22 eyes with drusenoid PED. In the final comparison, the mean CMT, SCT, and BCVA were significantly lower in Group 1 compared to Group 2 (P = 0.05; P = 0.05; P = 0.002, respectively). The mean CMT, SCT, and BCVA were significantly decreased from baseline to the last visit in Group 1 (P = 0.013; P < 0.001; P = 0.001, respectively). No significant changes were observed regarding the mean CMT, SCT, and BCVA in Group 2 during the follow-up visits. (P = 0.317, P = 0.682, P = 0.056). Conclusion: Spontaneous collapse of drusenoid PED is associated with poor visual outcome.https://journals.lww.com/10.4103/IJO.IJO_1966_24central macular thicknessdrusennon-neovascular age-related macular degenerationpigment epithelial detachmentsubfoveal choroidal thickness |
| spellingShingle | Sinem Karabulut Sema Tamer Kaderli Aylin Karalezli Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degeneration Indian Journal of Ophthalmology central macular thickness drusen non-neovascular age-related macular degeneration pigment epithelial detachment subfoveal choroidal thickness |
| title | Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degeneration |
| title_full | Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degeneration |
| title_fullStr | Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degeneration |
| title_full_unstemmed | Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degeneration |
| title_short | Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degeneration |
| title_sort | long term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age related macular degeneration |
| topic | central macular thickness drusen non-neovascular age-related macular degeneration pigment epithelial detachment subfoveal choroidal thickness |
| url | https://journals.lww.com/10.4103/IJO.IJO_1966_24 |
| work_keys_str_mv | AT sinemkarabulut longtermoutcomesofdrusenoidretinalpigmentepitheliumdetachmentineyeswithagerelatedmaculardegeneration AT sematamerkaderli longtermoutcomesofdrusenoidretinalpigmentepitheliumdetachmentineyeswithagerelatedmaculardegeneration AT aylinkaralezli longtermoutcomesofdrusenoidretinalpigmentepitheliumdetachmentineyeswithagerelatedmaculardegeneration |