Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degeneration
Purpose: We aim to evaluate the changes in the size of drusens and drusenoid pigment epithelial detachments (PED) in patients with age-related macular degeneration. Design: This study was designed as an observational retrospective cohort study. Methods: We evaluated eyes with drusenoid PED tracked u...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_1966_24 |
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| Summary: | Purpose:
We aim to evaluate the changes in the size of drusens and drusenoid pigment epithelial detachments (PED) in patients with age-related macular degeneration.
Design:
This study was designed as an observational retrospective cohort study.
Methods:
We evaluated eyes with drusenoid PED tracked using spectral-domain and enhanced depth imaging optical coherence tomography. The cases were classified according to the follow-up visits and divided into two groups as eyes with collapsed PED and persisting PED. The best-corrected visual acuity (BCVA), size of drusens and PED, central macular thickness (CMT), and subfoveal choroidal thickness (SCT) were recorded.
Results:
We included 11 patients’ 22 eyes with drusenoid PED. In the final comparison, the mean CMT, SCT, and BCVA were significantly lower in Group 1 compared to Group 2 (P = 0.05; P = 0.05; P = 0.002, respectively). The mean CMT, SCT, and BCVA were significantly decreased from baseline to the last visit in Group 1 (P = 0.013; P < 0.001; P = 0.001, respectively). No significant changes were observed regarding the mean CMT, SCT, and BCVA in Group 2 during the follow-up visits. (P = 0.317, P = 0.682, P = 0.056).
Conclusion:
Spontaneous collapse of drusenoid PED is associated with poor visual outcome. |
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| ISSN: | 0301-4738 1998-3689 |