Casein Kinase 2α Ablation Confers Protection Against Metabolic Dysfunction‐Associated Steatotic Liver Disease: Role of FUN14 Domain Containing 1‐Dependent Regulation of Mitophagy and Ferroptosis

Casein Kinase 2α Ablation Confers Protection Against Metabolic Dysfunction‐Associated Steatotic Liver Disease: Role of FUN14 Domain Containing 1‐Dependent Regulation of Mitophagy and Ferroptosis

ABSTRACT Mitochondrial dyshomeostasis provokes the onset of metabolic dysfunction‐associated steatotic liver disease (MASLD) although its precise involvement in particular mitophagy in MASLD remains elusive. This work evaluated the role of casein kinase 2α (CK2α) and FUNDC1 in high‐fat diet (HFD)‐ev...

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Bibliographic Details
Main Authors: Ke He, Meixiao Zhan, Xuanming Luo, Ruibing Li, Ling Lin, Jie Lin, Liheng Li, Hongdong Chen, Gary D. Lopaschuk, Hao Zhou, Fei Liu, Jun Ren
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:MedComm
Subjects:
casein kinase 2α
ferroptosis
FUN14 domain containing 1
MASLD
steatosis
Online Access:https://doi.org/10.1002/mco2.70277
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