Mode of birth and maternal depression/severe anxiety: Findings from Millennium Cohort Study.
<h4>Introduction</h4>Limited evidence exists on the association between mode of birth and long-term depression and/or severe anxiety in mothers. We aimed to examine the association between mode of birth and depression and/or severe anxiety by 14 years postpartum.<h4>Methods</h4&...
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Public Library of Science (PLoS)
2025-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0327129 |
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| author | Elizabeth O Bodunde Fergus P McCarthy Karen O'connor Karen Matvienko-Sikar Ali S Khashan |
| author_facet | Elizabeth O Bodunde Fergus P McCarthy Karen O'connor Karen Matvienko-Sikar Ali S Khashan |
| author_sort | Elizabeth O Bodunde |
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| description | <h4>Introduction</h4>Limited evidence exists on the association between mode of birth and long-term depression and/or severe anxiety in mothers. We aimed to examine the association between mode of birth and depression and/or severe anxiety by 14 years postpartum.<h4>Methods</h4>We used data from the Millennium Cohort Study. Data on mode of birth were collected when mothers were 9 months postpartum, and categorized as spontaneous vaginal birth (VB), assisted VB, induced VB, emergency cesarean section (CS), planned CS, and CS after induction. Depression/severe anxiety were collected as one variable and self reported by mothers at 9 months, 3, 5, 7, 11, and 14 years postpartum based on a doctor diagnosis. The primary outcome measure was a diagnosis of depression/severe anxiety up to 14 years postpartum. We used multivariable logistic regression models to estimate crude and adjusted odds ratios (OR) for the association between mode of birth and depression/severe anxiety by 14 years postpartum.<h4>Results</h4>There were 10,507 singleton mothers included in our analyses. Fully adjusted odds ratio (aOR)for the association between mode of birth and depression/severe anxiety by 14 years postpartum was induced VB, (aOR, 1.13 [95% CI], 1.01-2.28), assisted VB (aOR, 1.03 [95% CI], 0.89-1.19), Emergency CS, (aOR, 1.08 [95% CI], 0.92-1.27), planned CS (aOR, 1.09 [95% CI], 0.93-1.27), and CS after induction (aOR, 1.08 [95% CI], 0.91-1.28). Fully adjusted models did not report any significant association between mode of birth and depression/severe anxiety at other postpartum time points.<h4>Conclusions</h4>The present findings provide support for association between induction of labor and the risk of long-term depression/severe anxiety by 14 years postpartum. The findings provide no evidence to support association between other modes of birth and maternal depression/anxiety. |
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| institution | Matheson Library |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-c10ffe7f92f74aab8c332d8c1fb5db8f2025-07-10T05:31:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01206e032712910.1371/journal.pone.0327129Mode of birth and maternal depression/severe anxiety: Findings from Millennium Cohort Study.Elizabeth O BodundeFergus P McCarthyKaren O'connorKaren Matvienko-SikarAli S Khashan<h4>Introduction</h4>Limited evidence exists on the association between mode of birth and long-term depression and/or severe anxiety in mothers. We aimed to examine the association between mode of birth and depression and/or severe anxiety by 14 years postpartum.<h4>Methods</h4>We used data from the Millennium Cohort Study. Data on mode of birth were collected when mothers were 9 months postpartum, and categorized as spontaneous vaginal birth (VB), assisted VB, induced VB, emergency cesarean section (CS), planned CS, and CS after induction. Depression/severe anxiety were collected as one variable and self reported by mothers at 9 months, 3, 5, 7, 11, and 14 years postpartum based on a doctor diagnosis. The primary outcome measure was a diagnosis of depression/severe anxiety up to 14 years postpartum. We used multivariable logistic regression models to estimate crude and adjusted odds ratios (OR) for the association between mode of birth and depression/severe anxiety by 14 years postpartum.<h4>Results</h4>There were 10,507 singleton mothers included in our analyses. Fully adjusted odds ratio (aOR)for the association between mode of birth and depression/severe anxiety by 14 years postpartum was induced VB, (aOR, 1.13 [95% CI], 1.01-2.28), assisted VB (aOR, 1.03 [95% CI], 0.89-1.19), Emergency CS, (aOR, 1.08 [95% CI], 0.92-1.27), planned CS (aOR, 1.09 [95% CI], 0.93-1.27), and CS after induction (aOR, 1.08 [95% CI], 0.91-1.28). Fully adjusted models did not report any significant association between mode of birth and depression/severe anxiety at other postpartum time points.<h4>Conclusions</h4>The present findings provide support for association between induction of labor and the risk of long-term depression/severe anxiety by 14 years postpartum. The findings provide no evidence to support association between other modes of birth and maternal depression/anxiety.https://doi.org/10.1371/journal.pone.0327129 |
| spellingShingle | Elizabeth O Bodunde Fergus P McCarthy Karen O'connor Karen Matvienko-Sikar Ali S Khashan Mode of birth and maternal depression/severe anxiety: Findings from Millennium Cohort Study. PLoS ONE |
| title | Mode of birth and maternal depression/severe anxiety: Findings from Millennium Cohort Study. |
| title_full | Mode of birth and maternal depression/severe anxiety: Findings from Millennium Cohort Study. |
| title_fullStr | Mode of birth and maternal depression/severe anxiety: Findings from Millennium Cohort Study. |
| title_full_unstemmed | Mode of birth and maternal depression/severe anxiety: Findings from Millennium Cohort Study. |
| title_short | Mode of birth and maternal depression/severe anxiety: Findings from Millennium Cohort Study. |
| title_sort | mode of birth and maternal depression severe anxiety findings from millennium cohort study |
| url | https://doi.org/10.1371/journal.pone.0327129 |
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