Effect of adding technologically processed antibodies to interferon-gamma into a parent solution on the structural features of triglycine sulfate crystals grown from this solution
Objectives. Ferroelectric triglycine sulfate (TGS) belongs to a group of crystals whose properties are sensitive even to minor changes in growth conditions. The mechanism of spontaneous polarization in TGS is associated with the adjustment of protons which participate in the formation of hydrogen bo...
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2024-01-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/2011 |
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| author | G. O. Stepanov N. N. Rodionova R. R. Konstantinov K. A. Subbotin |
| author_facet | G. O. Stepanov N. N. Rodionova R. R. Konstantinov K. A. Subbotin |
| author_sort | G. O. Stepanov |
| collection | DOAJ |
| description | Objectives. Ferroelectric triglycine sulfate (TGS) belongs to a group of crystals whose properties are sensitive even to minor changes in growth conditions. The mechanism of spontaneous polarization in TGS is associated with the adjustment of protons which participate in the formation of hydrogen bonds. Therefore, the state of the parent solution plays an important role in the crystal formation. The study aims to investigate the structural features of TGS crystals grown using aqueous alcoholic solutions of technologically processed antibodies to interferon-gamma, in comparison with those of the crystals grown using the control solutions (technologically processed phosphate-buffered saline and intact aqueous alcoholic solution).Methods. X-ray diffraction assay and Raman spectroscopy.Results. The effect of solutions of the technologically processed antibodies to interferongamma added to a parent solution on the growth of TGS single crystals is established. This effect manifests in the changing in occupancy of the proton sublattice of the crystal grown from the parent solution containing technologically processed antibodies to interferon-gamma, as compared with the crystals grown from the control solutions. In the case of the crystal grown from the solution containing technologically processed antibodies to interferon-gamma, this change in the occupancy of the proton lattice is expressed in an increase in the length of N2–C3 bonds.Conclusions. Adding the technologically processed antibodies in the parent solution before the crystal growth can affect the structure of TGS crystals. |
| format | Article |
| id | doaj-art-c10f56b2a17040c88c9edbc3da21a7cf |
| institution | Matheson Library |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-c10f56b2a17040c88c9edbc3da21a7cf2025-08-04T10:19:40ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752024-01-0118651753310.32362/2410-6593-2023-18-6-517-5331737Effect of adding technologically processed antibodies to interferon-gamma into a parent solution on the structural features of triglycine sulfate crystals grown from this solutionG. O. Stepanov0N. N. Rodionova1R. R. Konstantinov2K. A. Subbotin3Materia Medica HoldingMateria Medica HoldingMateria Medica HoldingProkhorov General Physics Institute, Russian Academy of Sciences; Mendeleev University of Chemical Technology of RussiaObjectives. Ferroelectric triglycine sulfate (TGS) belongs to a group of crystals whose properties are sensitive even to minor changes in growth conditions. The mechanism of spontaneous polarization in TGS is associated with the adjustment of protons which participate in the formation of hydrogen bonds. Therefore, the state of the parent solution plays an important role in the crystal formation. The study aims to investigate the structural features of TGS crystals grown using aqueous alcoholic solutions of technologically processed antibodies to interferon-gamma, in comparison with those of the crystals grown using the control solutions (technologically processed phosphate-buffered saline and intact aqueous alcoholic solution).Methods. X-ray diffraction assay and Raman spectroscopy.Results. The effect of solutions of the technologically processed antibodies to interferongamma added to a parent solution on the growth of TGS single crystals is established. This effect manifests in the changing in occupancy of the proton sublattice of the crystal grown from the parent solution containing technologically processed antibodies to interferon-gamma, as compared with the crystals grown from the control solutions. In the case of the crystal grown from the solution containing technologically processed antibodies to interferon-gamma, this change in the occupancy of the proton lattice is expressed in an increase in the length of N2–C3 bonds.Conclusions. Adding the technologically processed antibodies in the parent solution before the crystal growth can affect the structure of TGS crystals.https://www.finechem-mirea.ru/jour/article/view/2011technologically processed antibodiestriglycine sulfatesingle crystalx-ray diffraction assayraman spectroscopy |
| spellingShingle | G. O. Stepanov N. N. Rodionova R. R. Konstantinov K. A. Subbotin Effect of adding technologically processed antibodies to interferon-gamma into a parent solution on the structural features of triglycine sulfate crystals grown from this solution Тонкие химические технологии technologically processed antibodies triglycine sulfate single crystal x-ray diffraction assay raman spectroscopy |
| title | Effect of adding technologically processed antibodies to interferon-gamma into a parent solution on the structural features of triglycine sulfate crystals grown from this solution |
| title_full | Effect of adding technologically processed antibodies to interferon-gamma into a parent solution on the structural features of triglycine sulfate crystals grown from this solution |
| title_fullStr | Effect of adding technologically processed antibodies to interferon-gamma into a parent solution on the structural features of triglycine sulfate crystals grown from this solution |
| title_full_unstemmed | Effect of adding technologically processed antibodies to interferon-gamma into a parent solution on the structural features of triglycine sulfate crystals grown from this solution |
| title_short | Effect of adding technologically processed antibodies to interferon-gamma into a parent solution on the structural features of triglycine sulfate crystals grown from this solution |
| title_sort | effect of adding technologically processed antibodies to interferon gamma into a parent solution on the structural features of triglycine sulfate crystals grown from this solution |
| topic | technologically processed antibodies triglycine sulfate single crystal x-ray diffraction assay raman spectroscopy |
| url | https://www.finechem-mirea.ru/jour/article/view/2011 |
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