Effects of antiretroviral resistance on outcomes and health care resource utilisation among people with HIV in the United States and Europe: a real-world survey

Effects of antiretroviral resistance on outcomes and health care resource utilisation among people with HIV in the United States and Europe: a real-world survey

Background: Despite advances in antiretroviral therapy (ART), resistance remains a barrier to effective HIV treatment. Objective: This study evaluated associations between ART drug resistance and treatment adherence, health care resource utilisation (HCRU), and quality of life (QoL) among people wit...

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Bibliographic Details
Main Authors: Mary J. Christoph, Megan Chen, Seojin Park, Woodie Zachry, Cassidy Trom, Will Ambler, Fritha Hennessy, Hannah Jones, Tim Holbrook
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:HIV Research & Clinical Practice
Subjects:
antiretroviral therapy
drug resistance
health care resource utilisation
patient-reported outcomes
people with hiv
Online Access:http://dx.doi.org/10.1080/25787489.2025.2526910
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Summary:Background: Despite advances in antiretroviral therapy (ART), resistance remains a barrier to effective HIV treatment. Objective: This study evaluated associations between ART drug resistance and treatment adherence, health care resource utilisation (HCRU), and quality of life (QoL) among people with HIV. Methods: A retrospective, observational study was conducted using the Adelphi HIV Disease Specific Programme™ (DSP) between 2021 and 2023 across the United States and Europe. Data were collected via physician surveys, patient record forms, and patient self-completion forms. Results: Data for 2006 people with HIV and resistance testing were contributed by 290 physicians, and 586 people with HIV provided patient data. Overall, 286 people with HIV (14%) had documented resistance. People with HIV with resistance had received more ART regimens than those without resistance (p < 0.0001) and had lower viral suppression rates (p = 0.004) and lower CD4 counts (p = 0.032). People with HIV with resistance reported lower treatment adherence (p = 0.017) but similar QoL compared to those without resistance. People with HIV with resistance also had significantly more HIV-related hospitalisations than those without resistance (p = 0.022). Conclusions: ART resistance was associated with higher HCRU and poorer health outcomes in people with HIV, underscoring the need for continued focus on adherence and resistance management.
ISSN:2578-7470

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