ROLE OF PAX-5 TRANSCRIPTION FACTOR IN IMMUNOLOGICAL PROCESSES

ROLE OF PAX-5 TRANSCRIPTION FACTOR IN IMMUNOLOGICAL PROCESSES

Abstract.  The  review  article  concerns  various  features  of  PAX-5  (paired  box  5)  transcription  factor,  its structure, functions, regulation of activity, involvement into differentiation and activation of B lymphocytes, switching to IgE synthesis, its role in oncogenesis, and a putative r...

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Bibliographic Details
Main Authors: V. N. Mineev, L. N. Sorokina, M. A. Nyoma, V. A. Ivanov, G. I. Lipkin
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2014-07-01
Series:Медицинская иммунология
Subjects:
pax-5
transcription factors
b lymphocytes
bronchial asthma
ige
Online Access:https://www.mimmun.ru/mimmun/article/view/597
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Summary:Abstract.  The  review  article  concerns  various  features  of  PAX-5  (paired  box  5)  transcription  factor,  its structure, functions, regulation of activity, involvement into differentiation and activation of B lymphocytes, switching to IgE synthesis, its role in oncogenesis, and a putative role of this factor for development of bronchial asthma.Further  insight  into  specific  properties  of  PAX-5  factor  in  bronchial  asthma  may  provide  a  promising approach to studying mechanisms of this disorder. (Med. Immunol., 2011, vol. 13, N 6, pp 569-580)
ISSN:1563-0625
2313-741X

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