The Rise, Fall, and Rethink of (Fluoro)quinolones: A Quick Rundown
Antibiotics have revolutionized medicine, with (fluoro)quinolones emerging as one of the most impactful classes of antibacterial agents. Since their introduction, four generations of (fluoro)quinolones have been developed, demonstrating a broad spectrum of activity, favourable pharmacokinetics, and...
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MDPI AG
2025-05-01
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| Online Access: | https://www.mdpi.com/2076-0817/14/6/525 |
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| author | Célia Fortuna Rodrigues Francisco Silva |
| author_facet | Célia Fortuna Rodrigues Francisco Silva |
| author_sort | Célia Fortuna Rodrigues |
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| description | Antibiotics have revolutionized medicine, with (fluoro)quinolones emerging as one of the most impactful classes of antibacterial agents. Since their introduction, four generations of (fluoro)quinolones have been developed, demonstrating a broad spectrum of activity, favourable pharmacokinetics, and clinical efficacy. However, the rise of multidrug-resistant pathogens has posed significant challenges to their continued effectiveness, particularly in healthcare settings. Among the main resistant species, <i>Staphylococcus aureus</i>, particularly methicillin-resistant strains (MRSA), <i>Klebsiella pneumoniae</i>, <i>Enterococcus</i> spp. (<i>E. faecium</i> and <i>E. faecalis</i>), <i>Campylobacter</i> spp., and <i>Acinetobacter baumannii</i> are the most important. This critical literature review provides an updated perspective on (fluoro)quinolones (old and new), encompassing their spectrum of activity, pharmacokinetics, mechanisms of resistance, and the role of antimicrobial stewardship in preserving their utility, to address the growing threat of resistance. |
| format | Article |
| id | doaj-art-c011e9e61d924b10b87edd2f21285bb9 |
| institution | Matheson Library |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Pathogens |
| spelling | doaj-art-c011e9e61d924b10b87edd2f21285bb92025-06-25T14:16:53ZengMDPI AGPathogens2076-08172025-05-0114652510.3390/pathogens14060525The Rise, Fall, and Rethink of (Fluoro)quinolones: A Quick RundownCélia Fortuna Rodrigues0Francisco Silva1Associate Laboratory i4HB—Institute for Health and Bioeconomy, University Institute of Health Sciences—CESPU (IUCS-CESPU), 4585-116 Gandra PRD, PortugalDepartment of Pharmaceutical Sciences, University Institute of Health Sciences—CESPU (IUCS-CESPU), 4585-116 Gandra PRD, PortugalAntibiotics have revolutionized medicine, with (fluoro)quinolones emerging as one of the most impactful classes of antibacterial agents. Since their introduction, four generations of (fluoro)quinolones have been developed, demonstrating a broad spectrum of activity, favourable pharmacokinetics, and clinical efficacy. However, the rise of multidrug-resistant pathogens has posed significant challenges to their continued effectiveness, particularly in healthcare settings. Among the main resistant species, <i>Staphylococcus aureus</i>, particularly methicillin-resistant strains (MRSA), <i>Klebsiella pneumoniae</i>, <i>Enterococcus</i> spp. (<i>E. faecium</i> and <i>E. faecalis</i>), <i>Campylobacter</i> spp., and <i>Acinetobacter baumannii</i> are the most important. This critical literature review provides an updated perspective on (fluoro)quinolones (old and new), encompassing their spectrum of activity, pharmacokinetics, mechanisms of resistance, and the role of antimicrobial stewardship in preserving their utility, to address the growing threat of resistance.https://www.mdpi.com/2076-0817/14/6/525quinolonesresistance to antimicrobials(fluoro)quinolonespharmacokineticsspectrum of activity |
| spellingShingle | Célia Fortuna Rodrigues Francisco Silva The Rise, Fall, and Rethink of (Fluoro)quinolones: A Quick Rundown Pathogens quinolones resistance to antimicrobials (fluoro)quinolones pharmacokinetics spectrum of activity |
| title | The Rise, Fall, and Rethink of (Fluoro)quinolones: A Quick Rundown |
| title_full | The Rise, Fall, and Rethink of (Fluoro)quinolones: A Quick Rundown |
| title_fullStr | The Rise, Fall, and Rethink of (Fluoro)quinolones: A Quick Rundown |
| title_full_unstemmed | The Rise, Fall, and Rethink of (Fluoro)quinolones: A Quick Rundown |
| title_short | The Rise, Fall, and Rethink of (Fluoro)quinolones: A Quick Rundown |
| title_sort | rise fall and rethink of fluoro quinolones a quick rundown |
| topic | quinolones resistance to antimicrobials (fluoro)quinolones pharmacokinetics spectrum of activity |
| url | https://www.mdpi.com/2076-0817/14/6/525 |
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