The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium
The investigation purpose was to study the effect of fabomotizole on blood microcirculation in intact and ischemic myocardium in conditions of acute ischemia of the heart muscle. The experiments were carried out on anesthetized (urethane, 1300 mg/kg, i.p.) white mongrel male rats weighing 220–250 g....
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2022-07-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/316 |
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| author | I. B. Tsorin S. A. Simonenko M. B. Vititnova S. A. Kryzhanovskiy |
| author_facet | I. B. Tsorin S. A. Simonenko M. B. Vititnova S. A. Kryzhanovskiy |
| author_sort | I. B. Tsorin |
| collection | DOAJ |
| description | The investigation purpose was to study the effect of fabomotizole on blood microcirculation in intact and ischemic myocardium in conditions of acute ischemia of the heart muscle. The experiments were carried out on anesthetized (urethane, 1300 mg/kg, i.p.) white mongrel male rats weighing 220–250 g. Acute myocardial ischemia was caused by occlusion of the left coronary artery. Blood microcirculation was evaluated by laser Doppler flowmetry using a computerized laser analyzer "LAKK-OP2". It was found that fabomotizole (15 mg/kg, i.v.) in an intact heart does not affect blood microcirculation. Immediately after coronary artery ligation in the myocardial ischemia zone, microcirculation decreases sharply (by about 30 %, p = 0.0106) and practically does not change in the conditionally intact myocardium. Fabomotizole, administered 5 minutes before occlusion of the coronary artery, prevented a decrease in microcirculation in the ischemiс zone of the myocardium. The ability of fabomotizole in conditions of acute myocardial ischemia to prevent a decrease in the level of microcirculation in the ischemic zone may contribute to the anti-ischemic activity of the drug. |
| format | Article |
| id | doaj-art-bff16d6eb00e40f3be18b8c1b67b63f0 |
| institution | Matheson Library |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2022-07-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-bff16d6eb00e40f3be18b8c1b67b63f02025-08-03T13:00:47ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302022-07-0102313510.37489/2587-7836-2022-2-31-35302The effect of fabomotizole on blood microcirculation in intact and ischemic myocardiumI. B. Tsorin0S. A. Simonenko1M. B. Vititnova2S. A. Kryzhanovskiy3FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”The investigation purpose was to study the effect of fabomotizole on blood microcirculation in intact and ischemic myocardium in conditions of acute ischemia of the heart muscle. The experiments were carried out on anesthetized (urethane, 1300 mg/kg, i.p.) white mongrel male rats weighing 220–250 g. Acute myocardial ischemia was caused by occlusion of the left coronary artery. Blood microcirculation was evaluated by laser Doppler flowmetry using a computerized laser analyzer "LAKK-OP2". It was found that fabomotizole (15 mg/kg, i.v.) in an intact heart does not affect blood microcirculation. Immediately after coronary artery ligation in the myocardial ischemia zone, microcirculation decreases sharply (by about 30 %, p = 0.0106) and practically does not change in the conditionally intact myocardium. Fabomotizole, administered 5 minutes before occlusion of the coronary artery, prevented a decrease in microcirculation in the ischemiс zone of the myocardium. The ability of fabomotizole in conditions of acute myocardial ischemia to prevent a decrease in the level of microcirculation in the ischemic zone may contribute to the anti-ischemic activity of the drug.https://www.pharmacokinetica.ru/jour/article/view/316acute myocardial ischemiablood microcirculationfabomotizolerats |
| spellingShingle | I. B. Tsorin S. A. Simonenko M. B. Vititnova S. A. Kryzhanovskiy The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium Фармакокинетика и Фармакодинамика acute myocardial ischemia blood microcirculation fabomotizole rats |
| title | The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium |
| title_full | The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium |
| title_fullStr | The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium |
| title_full_unstemmed | The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium |
| title_short | The effect of fabomotizole on blood microcirculation in intact and ischemic myocardium |
| title_sort | effect of fabomotizole on blood microcirculation in intact and ischemic myocardium |
| topic | acute myocardial ischemia blood microcirculation fabomotizole rats |
| url | https://www.pharmacokinetica.ru/jour/article/view/316 |
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