A non-fasting marker of metabolic syndrome in a high-risk population
Objective: The rising prevalence of metabolic syndrome among young adults has prompted studies of fasting triglyceride-glucose (TyG) index as a marker of insulin resistance. We aimed to evaluate metabolic syndrome in young adults using non-fasting TyG index and a high-risk genetic model, 22q11.2 mic...
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Elsevier
2025-07-01
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| Series: | The Journal of Nutrition, Health and Aging |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1279770725000971 |
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| author | Sabrina Cancelliere Tracy Heung Christina Blagojevic Sarah Malecki Satya Dash Anne S. Bassett |
| author_facet | Sabrina Cancelliere Tracy Heung Christina Blagojevic Sarah Malecki Satya Dash Anne S. Bassett |
| author_sort | Sabrina Cancelliere |
| collection | DOAJ |
| description | Objective: The rising prevalence of metabolic syndrome among young adults has prompted studies of fasting triglyceride-glucose (TyG) index as a marker of insulin resistance. We aimed to evaluate metabolic syndrome in young adults using non-fasting TyG index and a high-risk genetic model, 22q11.2 microdeletion. Methods: We assessed metabolic syndrome and its components in 350 adults (50.6% female) aged 18–59 (median 27.7, IQR 22.5–38.1) years with typical 22q11.2 microdeletions. We used multivariable logistic regression and receiver operating characteristic (ROC) curves to evaluate the association of non-fasting TyG index with metabolic syndrome. Results: Non-fasting TyG index was significantly associated with metabolic syndrome (OR 3.23, 95% CI 2.27–4.59, p < 0.0001), independent of age, sex, BMI, and hypothyroidism. Non-fasting TyG index was positively correlated with number of metabolic syndrome components per individual. In this high-risk population, prevalence of metabolic syndrome was 21.7% (60/277) among young adults (18−39 years), and 45.2% (33/73, p < 0.0001) among middle-aged adults (40−59 years). Non-fasting TyG index ≥4.81 was an effective indicator of prevalent metabolic syndrome, with an area under the ROC curve of 0.83 (95% CI 0.78−0.88). Conclusions: The results support non-fasting TyG index as a practical marker of metabolic syndrome, and by extension insulin resistance, encouraging future studies evaluating non-fasting TyG index in young adults as a predictor of cardiovascular disease later in life. The high prevalence of metabolic syndrome at a young age in 22q11.2 microdeletion demonstrates the potential value of this genetic high-risk population for future prospective studies, with animal and cellular models available. |
| format | Article |
| id | doaj-art-bfa1c885c0ee42b58d37e3085e8d70b6 |
| institution | Matheson Library |
| issn | 1760-4788 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Nutrition, Health and Aging |
| spelling | doaj-art-bfa1c885c0ee42b58d37e3085e8d70b62025-07-12T04:45:56ZengElsevierThe Journal of Nutrition, Health and Aging1760-47882025-07-01297100573A non-fasting marker of metabolic syndrome in a high-risk populationSabrina Cancelliere0Tracy Heung1Christina Blagojevic2Sarah Malecki3Satya Dash4Anne S. Bassett5Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, CanadaClinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; The Dalglish Family 22q Clinic, Toronto General Hospital, University Health Network, Toronto, Ontario, CanadaClinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, CanadaClinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, CanadaDepartment of Medicine, University Health Network, Toronto, Ontario, CanadaClinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; The Dalglish Family 22q Clinic, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Department of Medicine, University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto and University Health Network, Toronto, Ontario, Canada; Toronto Congenital Cardiac Centre for Adults, Division of Cardiology, University Health Network, Toronto, Ontario, Canada; Toronto General Hospital Research Institute and Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada; Corresponding author.Objective: The rising prevalence of metabolic syndrome among young adults has prompted studies of fasting triglyceride-glucose (TyG) index as a marker of insulin resistance. We aimed to evaluate metabolic syndrome in young adults using non-fasting TyG index and a high-risk genetic model, 22q11.2 microdeletion. Methods: We assessed metabolic syndrome and its components in 350 adults (50.6% female) aged 18–59 (median 27.7, IQR 22.5–38.1) years with typical 22q11.2 microdeletions. We used multivariable logistic regression and receiver operating characteristic (ROC) curves to evaluate the association of non-fasting TyG index with metabolic syndrome. Results: Non-fasting TyG index was significantly associated with metabolic syndrome (OR 3.23, 95% CI 2.27–4.59, p < 0.0001), independent of age, sex, BMI, and hypothyroidism. Non-fasting TyG index was positively correlated with number of metabolic syndrome components per individual. In this high-risk population, prevalence of metabolic syndrome was 21.7% (60/277) among young adults (18−39 years), and 45.2% (33/73, p < 0.0001) among middle-aged adults (40−59 years). Non-fasting TyG index ≥4.81 was an effective indicator of prevalent metabolic syndrome, with an area under the ROC curve of 0.83 (95% CI 0.78−0.88). Conclusions: The results support non-fasting TyG index as a practical marker of metabolic syndrome, and by extension insulin resistance, encouraging future studies evaluating non-fasting TyG index in young adults as a predictor of cardiovascular disease later in life. The high prevalence of metabolic syndrome at a young age in 22q11.2 microdeletion demonstrates the potential value of this genetic high-risk population for future prospective studies, with animal and cellular models available.http://www.sciencedirect.com/science/article/pii/S1279770725000971Metabolic syndromeInsulin resistanceEarly identificationYoung adults22q11.2 microdeletion |
| spellingShingle | Sabrina Cancelliere Tracy Heung Christina Blagojevic Sarah Malecki Satya Dash Anne S. Bassett A non-fasting marker of metabolic syndrome in a high-risk population The Journal of Nutrition, Health and Aging Metabolic syndrome Insulin resistance Early identification Young adults 22q11.2 microdeletion |
| title | A non-fasting marker of metabolic syndrome in a high-risk population |
| title_full | A non-fasting marker of metabolic syndrome in a high-risk population |
| title_fullStr | A non-fasting marker of metabolic syndrome in a high-risk population |
| title_full_unstemmed | A non-fasting marker of metabolic syndrome in a high-risk population |
| title_short | A non-fasting marker of metabolic syndrome in a high-risk population |
| title_sort | non fasting marker of metabolic syndrome in a high risk population |
| topic | Metabolic syndrome Insulin resistance Early identification Young adults 22q11.2 microdeletion |
| url | http://www.sciencedirect.com/science/article/pii/S1279770725000971 |
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