Current trends in the immunotherapy of metastatic and recurrent squamous cell carcinoma of the head and neck
The immune system plays a key role in the development and progression of head and neck squamous cell carcinoma. Understanding the dysregulation and blockage of the immune system of malignant tumors in this location can improve treatment outcomes. A special group is made up of patients who have a wid...
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2020-11-01
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| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/559 |
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| author | Yu. V. Kostalanova K. A. Ganina A. A. Makhonin A. G. Gabrielyan |
| author_facet | Yu. V. Kostalanova K. A. Ganina A. A. Makhonin A. G. Gabrielyan |
| author_sort | Yu. V. Kostalanova |
| collection | DOAJ |
| description | The immune system plays a key role in the development and progression of head and neck squamous cell carcinoma. Understanding the dysregulation and blockage of the immune system of malignant tumors in this location can improve treatment outcomes. A special group is made up of patients who have a widespread process and relapse after chemotherapy with platinum drugs, because they have a very poor prognosis and limitations in the possibilities of further treatment. To date, the most important data relate to drugs acting on the PD-1 (programmed cell death protein 1)/PD-L1 (programmed death ligand 1) immune checkpoints, which are used by the tumor to block the immune system, which have allowed to increase the effectiveness of treatment. The article presents a clinical case demonstrating the effectiveness of the use of checkpoint inhibitors after the use of platinum preparations. |
| format | Article |
| id | doaj-art-bfa0cea0535e461db7bef1cb9adff8c1 |
| institution | Matheson Library |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2020-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-bfa0cea0535e461db7bef1cb9adff8c12025-08-04T14:05:33ZrusABV-pressОпухоли головы и шеи2222-14682411-46342020-11-01103414710.17650/2222-1468-2020-10-3-41-47403Current trends in the immunotherapy of metastatic and recurrent squamous cell carcinoma of the head and neckYu. V. Kostalanova0K. A. Ganina1A. A. Makhonin2A. G. Gabrielyan3Samara Regional Clinical Oncology DispensarySamara State Medical University, Ministry of Health of RussiaSamara Regional Clinical Oncology Dispensary; Samara State Medical University, Ministry of Health of RussiaSamara Regional Clinical Oncology Dispensary; Samara State Medical University, Ministry of Health of RussiaThe immune system plays a key role in the development and progression of head and neck squamous cell carcinoma. Understanding the dysregulation and blockage of the immune system of malignant tumors in this location can improve treatment outcomes. A special group is made up of patients who have a widespread process and relapse after chemotherapy with platinum drugs, because they have a very poor prognosis and limitations in the possibilities of further treatment. To date, the most important data relate to drugs acting on the PD-1 (programmed cell death protein 1)/PD-L1 (programmed death ligand 1) immune checkpoints, which are used by the tumor to block the immune system, which have allowed to increase the effectiveness of treatment. The article presents a clinical case demonstrating the effectiveness of the use of checkpoint inhibitors after the use of platinum preparations.https://ogsh.abvpress.ru/jour/article/view/559immunotherapypembrolizumabnivolumabprogrammed cell death protein 1pd-1programmed cell death ligand 1pd-l1biomarkers |
| spellingShingle | Yu. V. Kostalanova K. A. Ganina A. A. Makhonin A. G. Gabrielyan Current trends in the immunotherapy of metastatic and recurrent squamous cell carcinoma of the head and neck Опухоли головы и шеи immunotherapy pembrolizumab nivolumab programmed cell death protein 1 pd-1 programmed cell death ligand 1 pd-l1 biomarkers |
| title | Current trends in the immunotherapy of metastatic and recurrent squamous cell carcinoma of the head and neck |
| title_full | Current trends in the immunotherapy of metastatic and recurrent squamous cell carcinoma of the head and neck |
| title_fullStr | Current trends in the immunotherapy of metastatic and recurrent squamous cell carcinoma of the head and neck |
| title_full_unstemmed | Current trends in the immunotherapy of metastatic and recurrent squamous cell carcinoma of the head and neck |
| title_short | Current trends in the immunotherapy of metastatic and recurrent squamous cell carcinoma of the head and neck |
| title_sort | current trends in the immunotherapy of metastatic and recurrent squamous cell carcinoma of the head and neck |
| topic | immunotherapy pembrolizumab nivolumab programmed cell death protein 1 pd-1 programmed cell death ligand 1 pd-l1 biomarkers |
| url | https://ogsh.abvpress.ru/jour/article/view/559 |
| work_keys_str_mv | AT yuvkostalanova currenttrendsintheimmunotherapyofmetastaticandrecurrentsquamouscellcarcinomaoftheheadandneck AT kaganina currenttrendsintheimmunotherapyofmetastaticandrecurrentsquamouscellcarcinomaoftheheadandneck AT aamakhonin currenttrendsintheimmunotherapyofmetastaticandrecurrentsquamouscellcarcinomaoftheheadandneck AT aggabrielyan currenttrendsintheimmunotherapyofmetastaticandrecurrentsquamouscellcarcinomaoftheheadandneck |