Effect of surgical margin status and pathological tumor stage on tumor recurrence after open partial nephrectomy
Introduction. Th e surgical margin status and pathological tumor stage constitute important factors affecting tumor recurrence after partial nephrectomy.Aim. To assess the role of surgical margin status and pathological tumor stage in tumor recurrence after open partial nephrectomy.Materials and met...
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Bashkir State Medical University
2024-04-01
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| Series: | Креативная хирургия и онкология |
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| Online Access: | https://www.surgonco.ru/jour/article/view/911 |
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| author | A. A. Seregin A. V. Seregin K. B. Kolontarev O. B. Loran |
| author_facet | A. A. Seregin A. V. Seregin K. B. Kolontarev O. B. Loran |
| author_sort | A. A. Seregin |
| collection | DOAJ |
| description | Introduction. Th e surgical margin status and pathological tumor stage constitute important factors affecting tumor recurrence after partial nephrectomy.Aim. To assess the role of surgical margin status and pathological tumor stage in tumor recurrence after open partial nephrectomy.Materials and methods. Th e retrospective study included 904 kidney cancer patients who underwent open partial nephrectomy from 2010 to 2019.Results. Renal cell carcinoma was found in 796 (88.1 %) patients. A negative surgical margin was detected in 735 (92.3 %) cases. Pathological stages were distributed as follows: pT1aN0M0 — 530 (66.6 %); pT1bN0M0 — 239 (30.0 %); pT2aN0M0 — 22 (2.8 %); pТ3aN0M0 — 5 (0.6 %). Median follow-up was 72 months. Th e recurrence rate amounted to 5.9 % (43/735) for negative surgical margins and 6.6 % (4/61) for positive surgical margins. Positive and negative surgical margins showed no significant difference in the risk of tumor recurrence (p > 0.05). Depending on the pathological stage, the following tumor recurrence rates were observed: pT1aN0M0 — 4,9 % (26/530); pT1bN0M0 — 7.5 % (18/239); pT2aN0M0 — 9.1 % (2/22); pТ3aN0M0 — 20.0 % (1/5). Th e risk of cancer recurrence was significantly higher in pT1b than in pT1a (p < 0.05), as well as in pT2 than in pT1 (p < 0.05).Discussion. In this study, the presence of a positive surgical margin had no effect on the kidney cancer recurrence rate. However, the retrospective nature of the study and the low incidence of positive margins necessitate further study of this issue.Conclusions. An increase in pathological tumor stage significantly affects the risk of tumor recurrence. A significant difference in recurrence rates is observed between stages T1a and T1b, as well as between stages T1 and T2. |
| format | Article |
| id | doaj-art-bf92fd574bf64f90bc3ad090e09bedb1 |
| institution | Matheson Library |
| issn | 2076-3093 2307-0501 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Bashkir State Medical University |
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| series | Креативная хирургия и онкология |
| spelling | doaj-art-bf92fd574bf64f90bc3ad090e09bedb12025-08-03T19:48:56ZengBashkir State Medical UniversityКреативная хирургия и онкология2076-30932307-05012024-04-01141131910.24060/2076-3093-2024-14-1-13-19558Effect of surgical margin status and pathological tumor stage on tumor recurrence after open partial nephrectomyA. A. Seregin0A. V. Seregin1K. B. Kolontarev2O. B. Loran3Russian Medical Academy of Postgraduate Education; Moscow Urology Center, S.P. Botkin City Clinical HospitalRussian Medical Academy of Postgraduate Education; Moscow Urology Center, S.P. Botkin City Clinical HospitalMoscow Urology Center, S.P. Botkin City Clinical Hospital; Russian University of MedicineRussian Medical Academy of Postgraduate Education; Moscow Urology Center, S.P. Botkin City Clinical HospitalIntroduction. Th e surgical margin status and pathological tumor stage constitute important factors affecting tumor recurrence after partial nephrectomy.Aim. To assess the role of surgical margin status and pathological tumor stage in tumor recurrence after open partial nephrectomy.Materials and methods. Th e retrospective study included 904 kidney cancer patients who underwent open partial nephrectomy from 2010 to 2019.Results. Renal cell carcinoma was found in 796 (88.1 %) patients. A negative surgical margin was detected in 735 (92.3 %) cases. Pathological stages were distributed as follows: pT1aN0M0 — 530 (66.6 %); pT1bN0M0 — 239 (30.0 %); pT2aN0M0 — 22 (2.8 %); pТ3aN0M0 — 5 (0.6 %). Median follow-up was 72 months. Th e recurrence rate amounted to 5.9 % (43/735) for negative surgical margins and 6.6 % (4/61) for positive surgical margins. Positive and negative surgical margins showed no significant difference in the risk of tumor recurrence (p > 0.05). Depending on the pathological stage, the following tumor recurrence rates were observed: pT1aN0M0 — 4,9 % (26/530); pT1bN0M0 — 7.5 % (18/239); pT2aN0M0 — 9.1 % (2/22); pТ3aN0M0 — 20.0 % (1/5). Th e risk of cancer recurrence was significantly higher in pT1b than in pT1a (p < 0.05), as well as in pT2 than in pT1 (p < 0.05).Discussion. In this study, the presence of a positive surgical margin had no effect on the kidney cancer recurrence rate. However, the retrospective nature of the study and the low incidence of positive margins necessitate further study of this issue.Conclusions. An increase in pathological tumor stage significantly affects the risk of tumor recurrence. A significant difference in recurrence rates is observed between stages T1a and T1b, as well as between stages T1 and T2.https://www.surgonco.ru/jour/article/view/911kidney cancerrenal cell carcinomapartial nephrectomypartial nephrectomysurgical marginpathological stagelocal tumor recurrence |
| spellingShingle | A. A. Seregin A. V. Seregin K. B. Kolontarev O. B. Loran Effect of surgical margin status and pathological tumor stage on tumor recurrence after open partial nephrectomy Креативная хирургия и онкология kidney cancer renal cell carcinoma partial nephrectomy partial nephrectomy surgical margin pathological stage local tumor recurrence |
| title | Effect of surgical margin status and pathological tumor stage on tumor recurrence after open partial nephrectomy |
| title_full | Effect of surgical margin status and pathological tumor stage on tumor recurrence after open partial nephrectomy |
| title_fullStr | Effect of surgical margin status and pathological tumor stage on tumor recurrence after open partial nephrectomy |
| title_full_unstemmed | Effect of surgical margin status and pathological tumor stage on tumor recurrence after open partial nephrectomy |
| title_short | Effect of surgical margin status and pathological tumor stage on tumor recurrence after open partial nephrectomy |
| title_sort | effect of surgical margin status and pathological tumor stage on tumor recurrence after open partial nephrectomy |
| topic | kidney cancer renal cell carcinoma partial nephrectomy partial nephrectomy surgical margin pathological stage local tumor recurrence |
| url | https://www.surgonco.ru/jour/article/view/911 |
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