Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials
Aim: This systematic review and meta-analysis aimed to evaluate the effects of Nigella sativa (N. sativa) supplementation on metabolic and cardiovascular health outcomes. Methods: A comprehensive search of EMBASE, Scopus, PubMed, CENTRAL, and Web of Science databases was conducted up to August 2024....
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Elsevier
2025-09-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S104366182500307X |
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| author | Ali Jafari Helia Mardani Amir Hossein Faghfouri Zahra Mirzaei Fashtali Mohtaram Hashemi Matin Abdollahi Yousefabady Reihane Javid Sahar Golabi Bahareh Arghavan Vali Musazadeh Mahshid Naghashpour |
| author_facet | Ali Jafari Helia Mardani Amir Hossein Faghfouri Zahra Mirzaei Fashtali Mohtaram Hashemi Matin Abdollahi Yousefabady Reihane Javid Sahar Golabi Bahareh Arghavan Vali Musazadeh Mahshid Naghashpour |
| author_sort | Ali Jafari |
| collection | DOAJ |
| description | Aim: This systematic review and meta-analysis aimed to evaluate the effects of Nigella sativa (N. sativa) supplementation on metabolic and cardiovascular health outcomes. Methods: A comprehensive search of EMBASE, Scopus, PubMed, CENTRAL, and Web of Science databases was conducted up to August 2024. Study quality and certainty of evidence were assessed using the Cochrane Risk of Bias and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tools, respectively. Results: Eighty-two studies, including 79 quantitative and 3 qualitative studies published between 2008 and 2024, involving 5026 participants with interventions ranging from 1 to 48 weeks and doses varying from 200 to 4600 mg/day, were included. N. sativa supplementation significantly improved body fat percentage (BF%), body mass index (BMI), skeletal muscle mass (SMM), waist circumference (WC), weight, waist-to-hip ratio (WHR), diastolic blood pressure (DBP), systolic blood pressure (SBP), mean arterial pressure (MAP), fasting blood sugar (FBS), hemoglobin A1c (HbA1c), postprandial blood glucose (PPBG), quick insulin sensitivity check index (QUICKI), C-reactive protein (CRP), high-sensitivity CRP (hs-CRP), intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), vascular cell adhesion molecule-1 (VCAM-1), atherogenic index (AI), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) to HDL-C ratio, TC, triglycerides (TG), very-low-density lipoprotein cholesterol (VLDL-C), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, urea, catalase (CAT), malondialdehyde (MDA), superoxide dismutase activity (SOD) activity, and total antioxidant capacity (TAC). Conclusions: Our findings suggest that N. sativa could be a promising adjunct therapy for improving cardiovascular disease (CVD) risk factors. |
| format | Article |
| id | doaj-art-bf3f051dabbd4a44b007098cf6091f6f |
| institution | Matheson Library |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
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| series | Pharmacological Research |
| spelling | doaj-art-bf3f051dabbd4a44b007098cf6091f6f2025-07-28T04:16:09ZengElsevierPharmacological Research1096-11862025-09-01219107882Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trialsAli Jafari0Helia Mardani1Amir Hossein Faghfouri2Zahra Mirzaei Fashtali3Mohtaram Hashemi4Matin Abdollahi Yousefabady5Reihane Javid6Sahar Golabi7Bahareh Arghavan8Vali Musazadeh9Mahshid Naghashpour10Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Corresponding author at: Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Student Research Committee, Department of Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, IranMaternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, IranStudent Research Committee, Semnan University of Medical Sciences, Semnan, IranStudent Research Committee, Semnan University of Medical Sciences, Semnan, IranStudent Research Committee, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Semnan University of Medical Sciences, Semnan, IranDepartment of Medical Physiology, School of Medicine, Abadan University of Medical Science, Abadan, IranDepartment of Laboratory Sciences, School of Medicine, Abadan University of Medical Sciences, Abadan, IranStudent Research Committee, Iran University of Medical Sciences, Tehran, Iran; Corresponding authors.Department of Nutrition, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran; Corresponding authors.Aim: This systematic review and meta-analysis aimed to evaluate the effects of Nigella sativa (N. sativa) supplementation on metabolic and cardiovascular health outcomes. Methods: A comprehensive search of EMBASE, Scopus, PubMed, CENTRAL, and Web of Science databases was conducted up to August 2024. Study quality and certainty of evidence were assessed using the Cochrane Risk of Bias and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tools, respectively. Results: Eighty-two studies, including 79 quantitative and 3 qualitative studies published between 2008 and 2024, involving 5026 participants with interventions ranging from 1 to 48 weeks and doses varying from 200 to 4600 mg/day, were included. N. sativa supplementation significantly improved body fat percentage (BF%), body mass index (BMI), skeletal muscle mass (SMM), waist circumference (WC), weight, waist-to-hip ratio (WHR), diastolic blood pressure (DBP), systolic blood pressure (SBP), mean arterial pressure (MAP), fasting blood sugar (FBS), hemoglobin A1c (HbA1c), postprandial blood glucose (PPBG), quick insulin sensitivity check index (QUICKI), C-reactive protein (CRP), high-sensitivity CRP (hs-CRP), intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), vascular cell adhesion molecule-1 (VCAM-1), atherogenic index (AI), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) to HDL-C ratio, TC, triglycerides (TG), very-low-density lipoprotein cholesterol (VLDL-C), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, urea, catalase (CAT), malondialdehyde (MDA), superoxide dismutase activity (SOD) activity, and total antioxidant capacity (TAC). Conclusions: Our findings suggest that N. sativa could be a promising adjunct therapy for improving cardiovascular disease (CVD) risk factors.http://www.sciencedirect.com/science/article/pii/S104366182500307XNigella sativaAnthropometric indicesLipid profileGlycemic controlLiver functionMeta-analysis |
| spellingShingle | Ali Jafari Helia Mardani Amir Hossein Faghfouri Zahra Mirzaei Fashtali Mohtaram Hashemi Matin Abdollahi Yousefabady Reihane Javid Sahar Golabi Bahareh Arghavan Vali Musazadeh Mahshid Naghashpour Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials Pharmacological Research Nigella sativa Anthropometric indices Lipid profile Glycemic control Liver function Meta-analysis |
| title | Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials |
| title_full | Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials |
| title_fullStr | Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials |
| title_full_unstemmed | Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials |
| title_short | Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials |
| title_sort | does nigella sativa supplementation improve cardiovascular disease risk factors a comprehensive grade assessed systematic review and dose response meta analysis of 82 randomized controlled trials |
| topic | Nigella sativa Anthropometric indices Lipid profile Glycemic control Liver function Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S104366182500307X |
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