BRAFV600E augments WNT signaling in colorectal cancer via aberrant DNA methylation

BRAFV600E augments WNT signaling in colorectal cancer via aberrant DNA methylation

Summary: The BRAFV600E mutation drives an aggressive subtype of colorectal cancer (CRC). Although WNT signaling activation is a hallmark of CRC, APC mutations are uncommon in BRAF-V600E mutant CRC, and RNF43 mutations are instead suspected to drive WNT pathway activation. Here, we investigated WNT p...

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Bibliographic Details
Main Authors: Layla El Bouazzaoui, Jeroen M. Bugter, Emre Küçükköse, André Verheem, Jasmin B. Post, Nicola Fenderico, Inne H.M. Borel Rinkes, Hugo J.G. Snippert, Madelon M. Maurice, Onno Kranenburg
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Epigenetics
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225009691
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