Proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in Lyme-borreliosis patients
The object of this work was to study the correlation between the lymphocyte proliferation and apoptosis in the cultures stimulated by specific inactivated Borrelia garinii antigen and the different clinical outcomes in Lyme borreliosis patients. It was found that borrelia antigen stimulation of the...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2012-08-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/533 |
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| author | Ye. N. Ilyinskikh I. N. Ilyinskikh A. G. Semyonov Ye. A. Fait M. V. Shaitarova |
| author_facet | Ye. N. Ilyinskikh I. N. Ilyinskikh A. G. Semyonov Ye. A. Fait M. V. Shaitarova |
| author_sort | Ye. N. Ilyinskikh |
| collection | DOAJ |
| description | The object of this work was to study the correlation between the lymphocyte proliferation and apoptosis in the cultures stimulated by specific inactivated Borrelia garinii antigen and the different clinical outcomes in Lyme borreliosis patients. It was found that borrelia antigen stimulation of the cultures obtained from chronic patients induced T helper type 1-like response as well as depression in lymphocyte apoptosis, which may provide the basis of persistent activated T cell immune response and chronic inflammatory in Lyme borreliosis. |
| format | Article |
| id | doaj-art-beb9a51a39f94fe29fd895c5145aa38d |
| institution | Matheson Library |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2012-08-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-beb9a51a39f94fe29fd895c5145aa38d2025-08-04T16:45:34ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842012-08-01114323810.20538/1682-0363-2012-4-32-38495Proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in Lyme-borreliosis patientsYe. N. Ilyinskikh0I. N. Ilyinskikh1A. G. Semyonov2Ye. A. Fait3M. V. Shaitarova4Сибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскThe object of this work was to study the correlation between the lymphocyte proliferation and apoptosis in the cultures stimulated by specific inactivated Borrelia garinii antigen and the different clinical outcomes in Lyme borreliosis patients. It was found that borrelia antigen stimulation of the cultures obtained from chronic patients induced T helper type 1-like response as well as depression in lymphocyte apoptosis, which may provide the basis of persistent activated T cell immune response and chronic inflammatory in Lyme borreliosis.https://bulletin.ssmu.ru/jour/article/view/533lyme borreliosisflow-cytometryapoptosiscell cyclebromodeoxyuridinelymphocyte transformation testborrelia gariniiinterferon-ginterleukin-4. |
| spellingShingle | Ye. N. Ilyinskikh I. N. Ilyinskikh A. G. Semyonov Ye. A. Fait M. V. Shaitarova Proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in Lyme-borreliosis patients Бюллетень сибирской медицины lyme borreliosis flow-cytometry apoptosis cell cycle bromodeoxyuridine lymphocyte transformation test borrelia garinii interferon-g interleukin-4. |
| title | Proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in Lyme-borreliosis patients |
| title_full | Proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in Lyme-borreliosis patients |
| title_fullStr | Proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in Lyme-borreliosis patients |
| title_full_unstemmed | Proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in Lyme-borreliosis patients |
| title_short | Proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in Lyme-borreliosis patients |
| title_sort | proliferation and apoptosis of lymphocytes in response to borrelia antigen stimulation in lyme borreliosis patients |
| topic | lyme borreliosis flow-cytometry apoptosis cell cycle bromodeoxyuridine lymphocyte transformation test borrelia garinii interferon-g interleukin-4. |
| url | https://bulletin.ssmu.ru/jour/article/view/533 |
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