Diagnostic Value of PET/CT for Ovarian Cancer Recurrence or Metastasis in Postoperative Patients With Elevated Serum CA125 Levels: A Systematic Review and Meta‐Analysis
ABSTRACT Background Ovarian cancer patients with elevated serum CA125 levels after operation have a high incidence of relapse or metastasis. 18F‐FDG PET/CT is an effective imaging method for identifying recurrent or metastatic lesions. This study systematically investigated the diagnostic value of 1...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-08-01
|
| Series: | Cancer Innovation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cai2.70015 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839635514105266176 |
|---|---|
| author | Zuowei Zou Luhua Xia Saikang Tang Lin Lin Quanyang Wu Donghui Hou Shijun Zhao |
| author_facet | Zuowei Zou Luhua Xia Saikang Tang Lin Lin Quanyang Wu Donghui Hou Shijun Zhao |
| author_sort | Zuowei Zou |
| collection | DOAJ |
| description | ABSTRACT Background Ovarian cancer patients with elevated serum CA125 levels after operation have a high incidence of relapse or metastasis. 18F‐FDG PET/CT is an effective imaging method for identifying recurrent or metastatic lesions. This study systematically investigated the diagnostic value of 18F‐FDG PET/CT in this patient population. Methods A systematic search of PubMed, Embase, Cochrane Library (Central), Web of Science (SCI‐Expanded), and Chinese databases (CNKI, VIP database, Wan Fang Data, CBM) was performed. Studies that evaluated the diagnostic value of 18F‐FDG PET/CT for relapse or dissemination in postoperative ovarian cancer patients with elevated serum CA125 levels were included. The methodological quality of the studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Data were analyzed for heterogeneity using Meta‐Disc 1.4 software. Sensitivity analysis and release bias evaluation were conducted using STATA 14.0 software. Thirteen studies (including 421 female patients) qualified for the meta‐analysis. The pooled sensitivity and specificity of 18F‐FDG PET/CT were 0.94 (95% CI: 0.91–0.97) and 0.83 (95% CI: 0.71–0.91), respectively. The pooled positive likelihood proportion was 4.59 (95% CI: 2.81–7.51), the pooled negative likelihood proportion was 0.09 (95% CI: 0.05–0.15), and the pooled diagnostic odds ratio was 64.22 (95% CI: 27.21–151.57). The area under the curve was 0.9379. A sensitivity analysis and publication bias test indicated that the outcomes were steady, and there was no reporting bias. Conclusions 18F‐FDG PET/CT has high diagnostic veracity for identifying recurrence or metastasis in ovarian cancer cases with increased serum CA125 levels after surgery. It can accurately detect recurrent or metastatic lesions, providing valuable information for clinical decision‐making. |
| format | Article |
| id | doaj-art-be964dde56e34d9cace9c4bff7f0bcd2 |
| institution | Matheson Library |
| issn | 2770-9191 2770-9183 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Innovation |
| spelling | doaj-art-be964dde56e34d9cace9c4bff7f0bcd22025-07-09T07:32:37ZengWileyCancer Innovation2770-91912770-91832025-08-0144n/an/a10.1002/cai2.70015Diagnostic Value of PET/CT for Ovarian Cancer Recurrence or Metastasis in Postoperative Patients With Elevated Serum CA125 Levels: A Systematic Review and Meta‐AnalysisZuowei Zou0Luhua Xia1Saikang Tang2Lin Lin3Quanyang Wu4Donghui Hou5Shijun Zhao6Department of Nuclear Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Nuclear Medicine Tumor Hospital Affiliated to Xinjiang Medical University Urumqi Xinjiang ChinaDepartment of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Nuclear Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaABSTRACT Background Ovarian cancer patients with elevated serum CA125 levels after operation have a high incidence of relapse or metastasis. 18F‐FDG PET/CT is an effective imaging method for identifying recurrent or metastatic lesions. This study systematically investigated the diagnostic value of 18F‐FDG PET/CT in this patient population. Methods A systematic search of PubMed, Embase, Cochrane Library (Central), Web of Science (SCI‐Expanded), and Chinese databases (CNKI, VIP database, Wan Fang Data, CBM) was performed. Studies that evaluated the diagnostic value of 18F‐FDG PET/CT for relapse or dissemination in postoperative ovarian cancer patients with elevated serum CA125 levels were included. The methodological quality of the studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Data were analyzed for heterogeneity using Meta‐Disc 1.4 software. Sensitivity analysis and release bias evaluation were conducted using STATA 14.0 software. Thirteen studies (including 421 female patients) qualified for the meta‐analysis. The pooled sensitivity and specificity of 18F‐FDG PET/CT were 0.94 (95% CI: 0.91–0.97) and 0.83 (95% CI: 0.71–0.91), respectively. The pooled positive likelihood proportion was 4.59 (95% CI: 2.81–7.51), the pooled negative likelihood proportion was 0.09 (95% CI: 0.05–0.15), and the pooled diagnostic odds ratio was 64.22 (95% CI: 27.21–151.57). The area under the curve was 0.9379. A sensitivity analysis and publication bias test indicated that the outcomes were steady, and there was no reporting bias. Conclusions 18F‐FDG PET/CT has high diagnostic veracity for identifying recurrence or metastasis in ovarian cancer cases with increased serum CA125 levels after surgery. It can accurately detect recurrent or metastatic lesions, providing valuable information for clinical decision‐making.https://doi.org/10.1002/cai2.70015carbohydrate antigen 125diagnostic accuracymetastasisovarian cancerPET/CTrecurrence |
| spellingShingle | Zuowei Zou Luhua Xia Saikang Tang Lin Lin Quanyang Wu Donghui Hou Shijun Zhao Diagnostic Value of PET/CT for Ovarian Cancer Recurrence or Metastasis in Postoperative Patients With Elevated Serum CA125 Levels: A Systematic Review and Meta‐Analysis Cancer Innovation carbohydrate antigen 125 diagnostic accuracy metastasis ovarian cancer PET/CT recurrence |
| title | Diagnostic Value of PET/CT for Ovarian Cancer Recurrence or Metastasis in Postoperative Patients With Elevated Serum CA125 Levels: A Systematic Review and Meta‐Analysis |
| title_full | Diagnostic Value of PET/CT for Ovarian Cancer Recurrence or Metastasis in Postoperative Patients With Elevated Serum CA125 Levels: A Systematic Review and Meta‐Analysis |
| title_fullStr | Diagnostic Value of PET/CT for Ovarian Cancer Recurrence or Metastasis in Postoperative Patients With Elevated Serum CA125 Levels: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | Diagnostic Value of PET/CT for Ovarian Cancer Recurrence or Metastasis in Postoperative Patients With Elevated Serum CA125 Levels: A Systematic Review and Meta‐Analysis |
| title_short | Diagnostic Value of PET/CT for Ovarian Cancer Recurrence or Metastasis in Postoperative Patients With Elevated Serum CA125 Levels: A Systematic Review and Meta‐Analysis |
| title_sort | diagnostic value of pet ct for ovarian cancer recurrence or metastasis in postoperative patients with elevated serum ca125 levels a systematic review and meta analysis |
| topic | carbohydrate antigen 125 diagnostic accuracy metastasis ovarian cancer PET/CT recurrence |
| url | https://doi.org/10.1002/cai2.70015 |
| work_keys_str_mv | AT zuoweizou diagnosticvalueofpetctforovariancancerrecurrenceormetastasisinpostoperativepatientswithelevatedserumca125levelsasystematicreviewandmetaanalysis AT luhuaxia diagnosticvalueofpetctforovariancancerrecurrenceormetastasisinpostoperativepatientswithelevatedserumca125levelsasystematicreviewandmetaanalysis AT saikangtang diagnosticvalueofpetctforovariancancerrecurrenceormetastasisinpostoperativepatientswithelevatedserumca125levelsasystematicreviewandmetaanalysis AT linlin diagnosticvalueofpetctforovariancancerrecurrenceormetastasisinpostoperativepatientswithelevatedserumca125levelsasystematicreviewandmetaanalysis AT quanyangwu diagnosticvalueofpetctforovariancancerrecurrenceormetastasisinpostoperativepatientswithelevatedserumca125levelsasystematicreviewandmetaanalysis AT donghuihou diagnosticvalueofpetctforovariancancerrecurrenceormetastasisinpostoperativepatientswithelevatedserumca125levelsasystematicreviewandmetaanalysis AT shijunzhao diagnosticvalueofpetctforovariancancerrecurrenceormetastasisinpostoperativepatientswithelevatedserumca125levelsasystematicreviewandmetaanalysis |