Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9
The role of cytochrome P450 isoforms CYP2C9 and in the metabolism of losartan described. Losartan pharmacokinetics data in humans and laboratory animals are presented. Examples of drug-drug interactions of substrate marker losartan of CYP2C9 of with different drugs are given. The results of studies...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2020-04-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/157 |
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| author | O. G. Gribakina G. B. Kolyvanov A. A. Litvin A. O. Viglinskaya V. P. Zherdev |
| author_facet | O. G. Gribakina G. B. Kolyvanov A. A. Litvin A. O. Viglinskaya V. P. Zherdev |
| author_sort | O. G. Gribakina |
| collection | DOAJ |
| description | The role of cytochrome P450 isoforms CYP2C9 and in the metabolism of losartan described. Losartan pharmacokinetics data in humans and laboratory animals are presented. Examples of drug-drug interactions of substrate marker losartan of CYP2C9 of with different drugs are given. The results of studies of the effects of afobazole, an inducer (rifampicin) and inhibitors (fluconazole) in effective doses on the pharmacokinetics of losartan. |
| format | Article |
| id | doaj-art-be8d71a044564c0c96c9986dcddfa1cb |
| institution | Matheson Library |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2020-04-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-be8d71a044564c0c96c9986dcddfa1cb2025-08-03T13:00:45ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302020-04-01012132156Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9O. G. Gribakina0G. B. Kolyvanov1A. A. Litvin2A. O. Viglinskaya3V. P. Zherdev4FSBSI «Zakusov Institute of Pharmacology»FSBSI «Zakusov Institute of Pharmacology»FSBSI «Zakusov Institute of Pharmacology»FSBSI «Zakusov Institute of Pharmacology»FSBSI «Zakusov Institute of Pharmacology»The role of cytochrome P450 isoforms CYP2C9 and in the metabolism of losartan described. Losartan pharmacokinetics data in humans and laboratory animals are presented. Examples of drug-drug interactions of substrate marker losartan of CYP2C9 of with different drugs are given. The results of studies of the effects of afobazole, an inducer (rifampicin) and inhibitors (fluconazole) in effective doses on the pharmacokinetics of losartan.https://www.pharmacokinetica.ru/jour/article/view/157цитохром р450cyp2c9лозартанфармакокинетикаметаболизммежлекарственное взаимодействиеафобазолрифампицинфлуконазолcytochrome p450cyp2c9losartanpharmacokineticsmetabolismdrug-drug interactionafobazolerifampicinfluconazole |
| spellingShingle | O. G. Gribakina G. B. Kolyvanov A. A. Litvin A. O. Viglinskaya V. P. Zherdev Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9 Фармакокинетика и Фармакодинамика цитохром р450 cyp2c9 лозартан фармакокинетика метаболизм межлекарственное взаимодействие афобазол рифампицин флуконазол cytochrome p450 cyp2c9 losartan pharmacokinetics metabolism drug-drug interaction afobazole rifampicin fluconazole |
| title | Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9 |
| title_full | Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9 |
| title_fullStr | Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9 |
| title_full_unstemmed | Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9 |
| title_short | Pharmacokinetic interaction of drugs, the metabolisable cytochrome P450 isoenzyme CYP2C9 |
| title_sort | pharmacokinetic interaction of drugs the metabolisable cytochrome p450 isoenzyme cyp2c9 |
| topic | цитохром р450 cyp2c9 лозартан фармакокинетика метаболизм межлекарственное взаимодействие афобазол рифампицин флуконазол cytochrome p450 cyp2c9 losartan pharmacokinetics metabolism drug-drug interaction afobazole rifampicin fluconazole |
| url | https://www.pharmacokinetica.ru/jour/article/view/157 |
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