Pharmacokinetics of Olivamide after Bolus Administration in Rats and Rabbits (a Pilot Study)

The pharmacokinetics of olivamide, a semisynthetic antitumor derivate of olivomycin A, were studied in rats and rabbits after bolus administration. Plasma concentrations of olivamide were determined by an HPLC assay. The decrease in olivamide levels in blood plasma was biphasic in both rats and rabb...

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Main Authors: Yu. A. Portnoy, S. A. Dovzhenko, M. B. Kobrin, M. I. Treshalin, V. A. Golobrodo, A. N. Tevyashova, A. A. Firsov
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2020-05-01
Series:Антибиотики и Химиотерапия
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Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/35
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