The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age
The search for reliable algorithms for diagnosing heart failure with preserved left ventricular ejection fraction (LVEF) in elderly patients is an urgent problem due to the low specificity of clinical manifestations and the peculiarities of involutive processes occurring in the human body. As an alt...
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| Format: | Article |
| Language: | Russian |
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SINAPS LLC
2021-03-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/1170 |
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| author | V. N. Larina V. I. Lunev |
| author_facet | V. N. Larina V. I. Lunev |
| author_sort | V. N. Larina |
| collection | DOAJ |
| description | The search for reliable algorithms for diagnosing heart failure with preserved left ventricular ejection fraction (LVEF) in elderly patients is an urgent problem due to the low specificity of clinical manifestations and the peculiarities of involutive processes occurring in the human body. As an alternative diagnostic approach, it is possible to determine in the blood laboratory biochemical markers — a promising method of diagnosis, prognosis and control of the effectiveness of treatment. The article examines the significance of myocardial stress markers (brain natriuretic peptide, N-terminal brain natriuretic peptide, median fragment of atrial natriuretic peptide); «mechanical» myocardial stress (soluble stimulating growth factor expressed by gene 2 — sST2), copeptin, galectin-3 in patients with heart failure and preserved LVEF, including older persons, as well as the possibility of their use in outpatient practice to predict the course of heart failure. The contribution of the multimarker model for a comprehensive assessment of prognosis is discussed, taking into account both the «hemodynamic» side of myocardial stress (pressure or volume overload, markers — natriuretic peptides), and «mechanical» (fibrosis / hypertrophy / heart remodeling, marker — sST2) myocardial changes. |
| format | Article |
| id | doaj-art-bdc00c1d29b646588f0cf68f13a214e2 |
| institution | Matheson Library |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2021-03-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-bdc00c1d29b646588f0cf68f13a214e22025-08-04T14:09:47ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642021-03-011129811010.20514/2226-6704-2021-11-2-98-110833The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older AgeV. N. Larina0V. I. Lunev1N.I. Pirogov Russian National Research Medical UniversityN.I. Pirogov Russian National Research Medical UniversityThe search for reliable algorithms for diagnosing heart failure with preserved left ventricular ejection fraction (LVEF) in elderly patients is an urgent problem due to the low specificity of clinical manifestations and the peculiarities of involutive processes occurring in the human body. As an alternative diagnostic approach, it is possible to determine in the blood laboratory biochemical markers — a promising method of diagnosis, prognosis and control of the effectiveness of treatment. The article examines the significance of myocardial stress markers (brain natriuretic peptide, N-terminal brain natriuretic peptide, median fragment of atrial natriuretic peptide); «mechanical» myocardial stress (soluble stimulating growth factor expressed by gene 2 — sST2), copeptin, galectin-3 in patients with heart failure and preserved LVEF, including older persons, as well as the possibility of their use in outpatient practice to predict the course of heart failure. The contribution of the multimarker model for a comprehensive assessment of prognosis is discussed, taking into account both the «hemodynamic» side of myocardial stress (pressure or volume overload, markers — natriuretic peptides), and «mechanical» (fibrosis / hypertrophy / heart remodeling, marker — sST2) myocardial changes.https://www.medarhive.ru/jour/article/view/1170chronic heart failurepreserved left ventricular ejection fractionoutpatientsolder age |
| spellingShingle | V. N. Larina V. I. Lunev The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age Архивъ внутренней медицины chronic heart failure preserved left ventricular ejection fraction outpatients older age |
| title | The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age |
| title_full | The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age |
| title_fullStr | The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age |
| title_full_unstemmed | The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age |
| title_short | The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age |
| title_sort | value of biomarkers in the diagnosis and prognosis of heart failure in older age |
| topic | chronic heart failure preserved left ventricular ejection fraction outpatients older age |
| url | https://www.medarhive.ru/jour/article/view/1170 |
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