CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS
A sufficient increase of infectious complications rate during early posttransplant period in allogeneic bone marrow (allo-BM) recipients has been traditionally explained by the prominent drop of serum IgG levels in the patients. That was the main reason for therapeutic application of intravenous hum...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/94 |
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| author | A. V. Klimovich M. T. Van Lint M. P. Samoilovich B. V. Afanasiev V. B. Klimovich |
| author_facet | A. V. Klimovich M. T. Van Lint M. P. Samoilovich B. V. Afanasiev V. B. Klimovich |
| author_sort | A. V. Klimovich |
| collection | DOAJ |
| description | A sufficient increase of infectious complications rate during early posttransplant period in allogeneic bone marrow (allo-BM) recipients has been traditionally explained by the prominent drop of serum IgG levels in the patients. That was the main reason for therapeutic application of intravenous human immunoglobulins in allo-BM-recipients. In present study, multiple repeated measurements of different IgG subclasses were performed in blood serum of thirty-six patients at early terms after allogenic bone marrow transplantation period, along with analysis of individual clinical data. The study revealed several factors that show significant associations with IgG levels posttransplant. Moderate decrease in concentrations of IgG subclasses was registered after conditioning treatment carried out before the transplantation. Significantly decreased concentrations of IgG subclasses have been revealed during bleedings, diarrhea and glucocorticosteroid therapy. In general, however, no regular prolonged deficiency for total IgG subclasses was found in allogeneic bone marrow recipients during early posttransplant period. |
| format | Article |
| id | doaj-art-bda7c23e97b142d88f698a8f85a1d7b7 |
| institution | Matheson Library |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-bda7c23e97b142d88f698a8f85a1d7b72025-08-04T14:30:27ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01111414810.15789/1563-0625-2009-1-41-4892CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTSA. V. Klimovich0M. T. Van Lint1M. P. Samoilovich2B. V. Afanasiev3V. B. Klimovich4ГУЗ «Городская Клиническая больница № 31», Санкт-ПетербургЦентр трансплантации костного мозга Ospedale San-Martino, г. ГенуяРоссийский научный центр радиологии и хирургических технологий, Санкт-ПетербургГУЗ «Городская Клиническая больница № 31», Санкт-ПетербургРоссийский научный центр радиологии и хирургических технологий, Санкт-ПетербургA sufficient increase of infectious complications rate during early posttransplant period in allogeneic bone marrow (allo-BM) recipients has been traditionally explained by the prominent drop of serum IgG levels in the patients. That was the main reason for therapeutic application of intravenous human immunoglobulins in allo-BM-recipients. In present study, multiple repeated measurements of different IgG subclasses were performed in blood serum of thirty-six patients at early terms after allogenic bone marrow transplantation period, along with analysis of individual clinical data. The study revealed several factors that show significant associations with IgG levels posttransplant. Moderate decrease in concentrations of IgG subclasses was registered after conditioning treatment carried out before the transplantation. Significantly decreased concentrations of IgG subclasses have been revealed during bleedings, diarrhea and glucocorticosteroid therapy. In general, however, no regular prolonged deficiency for total IgG subclasses was found in allogeneic bone marrow recipients during early posttransplant period.https://www.mimmun.ru/mimmun/article/view/94igg subclassesallogeneic bone marrowearly posttransplant periodimmunoglobulins catabolism |
| spellingShingle | A. V. Klimovich M. T. Van Lint M. P. Samoilovich B. V. Afanasiev V. B. Klimovich CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS Медицинская иммунология igg subclasses allogeneic bone marrow early posttransplant period immunoglobulins catabolism |
| title | CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS |
| title_full | CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS |
| title_fullStr | CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS |
| title_full_unstemmed | CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS |
| title_short | CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS |
| title_sort | concentrations of igg subclasses in allogeneic bone marrow recipients |
| topic | igg subclasses allogeneic bone marrow early posttransplant period immunoglobulins catabolism |
| url | https://www.mimmun.ru/mimmun/article/view/94 |
| work_keys_str_mv | AT avklimovich concentrationsofiggsubclassesinallogeneicbonemarrowrecipients AT mtvanlint concentrationsofiggsubclassesinallogeneicbonemarrowrecipients AT mpsamoilovich concentrationsofiggsubclassesinallogeneicbonemarrowrecipients AT bvafanasiev concentrationsofiggsubclassesinallogeneicbonemarrowrecipients AT vbklimovich concentrationsofiggsubclassesinallogeneicbonemarrowrecipients |