Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing
<b>Background:</b> Wound healing in diabetic individuals is a prolonged process, often complicated by infections and impaired tissue regeneration. Innovative strategies combining natural bioactive compounds are needed to enhance repair. <b>Methods:</b> This study reports the...
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MDPI AG
2025-07-01
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| author | Franciéle M. Silva Jaqueline R. Silva Wellington Rodrigues Breno A. S. M. Sousa Thamis F. S. Gomes Mario F. F. Rosa Suélia S. R. F. Rosa Marcella L. B. Carneiro |
| author_facet | Franciéle M. Silva Jaqueline R. Silva Wellington Rodrigues Breno A. S. M. Sousa Thamis F. S. Gomes Mario F. F. Rosa Suélia S. R. F. Rosa Marcella L. B. Carneiro |
| author_sort | Franciéle M. Silva |
| collection | DOAJ |
| description | <b>Background:</b> Wound healing in diabetic individuals is a prolonged process, often complicated by infections and impaired tissue regeneration. Innovative strategies combining natural bioactive compounds are needed to enhance repair. <b>Methods:</b> This study reports the development and characterization of natural latex-based biomembranes (NLBs) incorporated with liposome-encapsulated curcumin and papain. The therapeutic efficacy of these composite dressings, in combination with red light-emitting diode (LED) phototherapy, was evaluated in a diabetic rat model. NLBs were produced by blending natural latex with multilamellar liposomes containing either curcumin, papain, or both. In vivo wound healing was assessed by applying the biomembranes to the dorsal lesions and administering red LED irradiation (650 ± 20 nm, 10 min every 48 h) over 11 days. <b>Results:</b> Fourier transform infrared spectroscopy (FTIR) confirmed that the integration of liposomes did not induce significant chemical alterations to the latex matrix. The treated diabetic rats exhibited enhanced wound contraction, with the curcumin and papain groups demonstrating up to 99% and 95% healing, respectively. Plasma fructosamine levels were significantly reduced (<i>p</i> < 0.05), indicating improved glycemic control. <b>Conclusions:</b> Combining NLBs with bioactive-loaded liposomes and phototherapy accelerated wound healing in diabetic rats. This multifunctional platform shows promise for the treatment of chronic wounds in diabetic patients. |
| format | Article |
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| language | English |
| publishDate | 2025-07-01 |
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| series | Pharmaceuticals |
| spelling | doaj-art-bd4ea11ee5a14baba3f1e8875f53d0a32025-07-25T13:33:25ZengMDPI AGPharmaceuticals1424-82472025-07-01187106710.3390/ph18071067Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound HealingFranciéle M. Silva0Jaqueline R. Silva1Wellington Rodrigues2Breno A. S. M. Sousa3Thamis F. S. Gomes4Mario F. F. Rosa5Suélia S. R. F. Rosa6Marcella L. B. Carneiro7Institute of Biological Sciences, University of Brasília, Brasília 73345-010, DF, BrazilInstitute of Biological Sciences, University of Brasília, Brasília 73345-010, DF, BrazilFaculty of Gama, University of Brasília, Brasília 73345-010, DF, BrazilFaculty of Gama, University of Brasília, Brasília 73345-010, DF, BrazilLaboratory of Bioactive Compounds and Nanobiotechnology (LCBNano), Campus Darcy Ribeiro, University of Brasilia, Brasilia 70910-900, DF, BrazilFaculty of Gama, University of Brasília, Brasília 73345-010, DF, BrazilMeinig School of Biomedical Engineering, Master of Engineering Program, Cornell University, Ithaca, NY 14850, USALaboratory of Bioactive Compounds and Nanobiotechnology (LCBNano), Campus Darcy Ribeiro, University of Brasilia, Brasilia 70910-900, DF, Brazil<b>Background:</b> Wound healing in diabetic individuals is a prolonged process, often complicated by infections and impaired tissue regeneration. Innovative strategies combining natural bioactive compounds are needed to enhance repair. <b>Methods:</b> This study reports the development and characterization of natural latex-based biomembranes (NLBs) incorporated with liposome-encapsulated curcumin and papain. The therapeutic efficacy of these composite dressings, in combination with red light-emitting diode (LED) phototherapy, was evaluated in a diabetic rat model. NLBs were produced by blending natural latex with multilamellar liposomes containing either curcumin, papain, or both. In vivo wound healing was assessed by applying the biomembranes to the dorsal lesions and administering red LED irradiation (650 ± 20 nm, 10 min every 48 h) over 11 days. <b>Results:</b> Fourier transform infrared spectroscopy (FTIR) confirmed that the integration of liposomes did not induce significant chemical alterations to the latex matrix. The treated diabetic rats exhibited enhanced wound contraction, with the curcumin and papain groups demonstrating up to 99% and 95% healing, respectively. Plasma fructosamine levels were significantly reduced (<i>p</i> < 0.05), indicating improved glycemic control. <b>Conclusions:</b> Combining NLBs with bioactive-loaded liposomes and phototherapy accelerated wound healing in diabetic rats. This multifunctional platform shows promise for the treatment of chronic wounds in diabetic patients.https://www.mdpi.com/1424-8247/18/7/1067diabeteswound dressingwound healingnanotechnologylatexcurcumin |
| spellingShingle | Franciéle M. Silva Jaqueline R. Silva Wellington Rodrigues Breno A. S. M. Sousa Thamis F. S. Gomes Mario F. F. Rosa Suélia S. R. F. Rosa Marcella L. B. Carneiro Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing Pharmaceuticals diabetes wound dressing wound healing nanotechnology latex curcumin |
| title | Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing |
| title_full | Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing |
| title_fullStr | Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing |
| title_full_unstemmed | Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing |
| title_short | Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing |
| title_sort | curcumin and papain loaded liposomal natural latex dressings with phototherapy a synergistic approach to diabetic wound healing |
| topic | diabetes wound dressing wound healing nanotechnology latex curcumin |
| url | https://www.mdpi.com/1424-8247/18/7/1067 |
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