A 90 g/day low‐carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial
ABSTRACT Aims This study explored the glycemic control and Fried frailty criteria of a 90 g/day low‐carbohydrate diet (LCD) in older patients with type 2 diabetes over 18 months. Methods Forty‐four older patients with type 2 diabetes and HbA1c ≥ 7.5% (58 mmol/mol) at the outpatient clinics were rand...
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Wiley
2025-08-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.70083 |
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| author | Yu‐Ting Wang Chin‐Ying Chen Wei‐Sheng Huang Hui‐Chuen Chen Long‐Teng Lee Chyi‐Feng Jan Hsien‐Liang Huang Jaw‐Shiun Tsai |
| author_facet | Yu‐Ting Wang Chin‐Ying Chen Wei‐Sheng Huang Hui‐Chuen Chen Long‐Teng Lee Chyi‐Feng Jan Hsien‐Liang Huang Jaw‐Shiun Tsai |
| author_sort | Yu‐Ting Wang |
| collection | DOAJ |
| description | ABSTRACT Aims This study explored the glycemic control and Fried frailty criteria of a 90 g/day low‐carbohydrate diet (LCD) in older patients with type 2 diabetes over 18 months. Methods Forty‐four older patients with type 2 diabetes and HbA1c ≥ 7.5% (58 mmol/mol) at the outpatient clinics were randomly assigned to a 90 g/day LCD or traditional diabetic diet (TDD). The analysis was performed using an intention‐to‐treat analysis. Results A total of 42 (95.5%) patients completed the trial. The 18‐month mean change from baseline was statistically significant for 2‐h glucose (−100.0 ± 57.7 vs −18.6 ± 86.2 mg/dL) and waist circumference (−6.3 ± 7.9 vs −1.7 ± 4.7 cm) between the LCD and TDD groups (P < 0.05). The 18‐month mean change from baseline was not significantly different in HbA1c (−1.55 ± 1.0 vs −0.97 ± 1.2; P = 0.097). After intervention, the proportions of robust, pre‐frailty, and frailty in the TDD and LCD groups were 20.0% vs 13.6%, 75.0% vs 86.4%, and 5.0% vs 0.0%, respectively (P > 0.05). Conclusions A 90 g/d LCD reflected improved glycemic control with significantly lower waist circumference without decreasing frailty in older patients with type 2 diabetes. |
| format | Article |
| id | doaj-art-bd3fd38a12324e2bb0810f1d8c4b146a |
| institution | Matheson Library |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-bd3fd38a12324e2bb0810f1d8c4b146a2025-08-01T12:51:37ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-08-011681398140810.1111/jdi.70083A 90 g/day low‐carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trialYu‐Ting Wang0Chin‐Ying Chen1Wei‐Sheng Huang2Hui‐Chuen Chen3Long‐Teng Lee4Chyi‐Feng Jan5Hsien‐Liang Huang6Jaw‐Shiun Tsai7Department of Family Medicine, Yunlin Branch National Taiwan University Hospital Huwei Township Yunlin County TaiwanDepartment of Family Medicine National Taiwan University Hospital and National Taiwan University Taipei TaiwanDepartment of Family Medicine National Taiwan University Hospital and National Taiwan University Taipei TaiwanDepartment of Dietetics National Taiwan University Hospital and National Taiwan University Taipei TaiwanDepartment of Family Medicine National Taiwan University Hospital and National Taiwan University Taipei TaiwanDepartment of Family Medicine National Taiwan University Hospital and National Taiwan University Taipei TaiwanDepartment of Family Medicine National Taiwan University Hospital and National Taiwan University Taipei TaiwanDepartment of Family Medicine National Taiwan University Hospital and National Taiwan University Taipei TaiwanABSTRACT Aims This study explored the glycemic control and Fried frailty criteria of a 90 g/day low‐carbohydrate diet (LCD) in older patients with type 2 diabetes over 18 months. Methods Forty‐four older patients with type 2 diabetes and HbA1c ≥ 7.5% (58 mmol/mol) at the outpatient clinics were randomly assigned to a 90 g/day LCD or traditional diabetic diet (TDD). The analysis was performed using an intention‐to‐treat analysis. Results A total of 42 (95.5%) patients completed the trial. The 18‐month mean change from baseline was statistically significant for 2‐h glucose (−100.0 ± 57.7 vs −18.6 ± 86.2 mg/dL) and waist circumference (−6.3 ± 7.9 vs −1.7 ± 4.7 cm) between the LCD and TDD groups (P < 0.05). The 18‐month mean change from baseline was not significantly different in HbA1c (−1.55 ± 1.0 vs −0.97 ± 1.2; P = 0.097). After intervention, the proportions of robust, pre‐frailty, and frailty in the TDD and LCD groups were 20.0% vs 13.6%, 75.0% vs 86.4%, and 5.0% vs 0.0%, respectively (P > 0.05). Conclusions A 90 g/d LCD reflected improved glycemic control with significantly lower waist circumference without decreasing frailty in older patients with type 2 diabetes.https://doi.org/10.1111/jdi.70083DiabetesFrailtyLow‐carbohydrate diet |
| spellingShingle | Yu‐Ting Wang Chin‐Ying Chen Wei‐Sheng Huang Hui‐Chuen Chen Long‐Teng Lee Chyi‐Feng Jan Hsien‐Liang Huang Jaw‐Shiun Tsai A 90 g/day low‐carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial Journal of Diabetes Investigation Diabetes Frailty Low‐carbohydrate diet |
| title | A 90 g/day low‐carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial |
| title_full | A 90 g/day low‐carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial |
| title_fullStr | A 90 g/day low‐carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial |
| title_full_unstemmed | A 90 g/day low‐carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial |
| title_short | A 90 g/day low‐carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial |
| title_sort | 90 g day low carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes a secondary analysis of a randomized controlled trial |
| topic | Diabetes Frailty Low‐carbohydrate diet |
| url | https://doi.org/10.1111/jdi.70083 |
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