Viral mitochondriopathy in COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), disrupts cellular mitochondria, leading to widespread chronic inflammation and multi-organ dysfunction. Viral proteins cause mitochondrial bioenergetic collapse, disrupt mitochondrial dyna...
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| Main Authors: | , , , , , |
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| 格式: | Article |
| 語言: | 英语 |
| 出版: |
Elsevier
2025-09-01
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| 叢編: | Redox Biology |
| 主題: | |
| 在線閱讀: | http://www.sciencedirect.com/science/article/pii/S2213231725002794 |
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| 總結: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), disrupts cellular mitochondria, leading to widespread chronic inflammation and multi-organ dysfunction. Viral proteins cause mitochondrial bioenergetic collapse, disrupt mitochondrial dynamics, and impair ionic homeostasis, while avoiding antiviral defenses, including mitochondrial antiviral signaling. These changes drive both acute COVID-19 and its longer-term effects, known as “long COVID”. This review examines new findings on the mechanisms by which SARS-CoV-2 affects mitochondria and for the impact on chronic immunity, long-term health risks, and potential treatments. |
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| ISSN: | 2213-2317 |