Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications
Photoactivatable aptamer sensing technology is widely used in various detection fields due to its precise spatiotemporal regulation ability, flexible material compatibility, and excellent detection performance. By introducing an optical response mechanism to regulate the efficient recognition of the...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/15/6/336 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839654612801421312 |
|---|---|
| author | Siyuan Wang Xinyun Cui Zixuan Zhong Jingjing Zhang |
| author_facet | Siyuan Wang Xinyun Cui Zixuan Zhong Jingjing Zhang |
| author_sort | Siyuan Wang |
| collection | DOAJ |
| description | Photoactivatable aptamer sensing technology is widely used in various detection fields due to its precise spatiotemporal regulation ability, flexible material compatibility, and excellent detection performance. By introducing an optical response mechanism to regulate the efficient recognition of the target by the sensor, this strategy further broadens the regulation means of the aptamer. The application of photoactivated aptamer biosensors in point-of-care testing (POCT) can significantly improve the selectivity, sensitivity, and dynamic response ability of the POCT system. This review systematically explores the design principle and regulation mechanism of photoactivatable aptamers, with a focus on reviewing the application progress of them in the POCT platform. In addition, the existing challenges and future development trends are also discussed. It is expected that this biosensor based on photoactivatable aptamers will continue to drive POCT towards higher sensitivity, intelligence, and scene adaptability, providing innovative tools for precision medicine and environmental health monitoring. |
| format | Article |
| id | doaj-art-bc9d5e206d504a258b68d6f3e3d4ff9d |
| institution | Matheson Library |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-bc9d5e206d504a258b68d6f3e3d4ff9d2025-06-25T13:33:52ZengMDPI AGBiosensors2079-63742025-05-0115633610.3390/bios15060336Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and ApplicationsSiyuan Wang0Xinyun Cui1Zixuan Zhong2Jingjing Zhang3State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, ChinaSchool of Life Sciences, Nanjing University, Nanjing 210023, ChinaState Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, ChinaState Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, ChinaPhotoactivatable aptamer sensing technology is widely used in various detection fields due to its precise spatiotemporal regulation ability, flexible material compatibility, and excellent detection performance. By introducing an optical response mechanism to regulate the efficient recognition of the target by the sensor, this strategy further broadens the regulation means of the aptamer. The application of photoactivated aptamer biosensors in point-of-care testing (POCT) can significantly improve the selectivity, sensitivity, and dynamic response ability of the POCT system. This review systematically explores the design principle and regulation mechanism of photoactivatable aptamers, with a focus on reviewing the application progress of them in the POCT platform. In addition, the existing challenges and future development trends are also discussed. It is expected that this biosensor based on photoactivatable aptamers will continue to drive POCT towards higher sensitivity, intelligence, and scene adaptability, providing innovative tools for precision medicine and environmental health monitoring.https://www.mdpi.com/2079-6374/15/6/336photoactivatableaptamersbiosensorspoint-of-care testing (POCT) |
| spellingShingle | Siyuan Wang Xinyun Cui Zixuan Zhong Jingjing Zhang Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications Biosensors photoactivatable aptamers biosensors point-of-care testing (POCT) |
| title | Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications |
| title_full | Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications |
| title_fullStr | Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications |
| title_full_unstemmed | Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications |
| title_short | Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications |
| title_sort | photoactivatable aptamer based biosensors for point of care testing advances and applications |
| topic | photoactivatable aptamers biosensors point-of-care testing (POCT) |
| url | https://www.mdpi.com/2079-6374/15/6/336 |
| work_keys_str_mv | AT siyuanwang photoactivatableaptamerbasedbiosensorsforpointofcaretestingadvancesandapplications AT xinyuncui photoactivatableaptamerbasedbiosensorsforpointofcaretestingadvancesandapplications AT zixuanzhong photoactivatableaptamerbasedbiosensorsforpointofcaretestingadvancesandapplications AT jingjingzhang photoactivatableaptamerbasedbiosensorsforpointofcaretestingadvancesandapplications |