Effects of a New Kappa Agonist (Fluorophenyl Derivative of Imidazo[1,2-<i>а</i>]benzimidazole) on the Rat Genome

Effects of a New Kappa Agonist (Fluorophenyl Derivative of Imidazo[1,2-<i>а</i>]benzimidazole) on the Rat Genome

Selective kappa-opioid receptor (KOR) agonists are considered a promising group of substances for developing opioid analgesics characterised with an original mechanism of action without the risk of respiratory depression and drug addiction. Previous studies identified a fluorophenyl derivative of im...

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Bibliographic Details
Main Authors: O. V. Verle, A. G. Sirekanyan, N. V. Eliseeva, Yu. V. Lifanova, A. A. Spasov, O. V. Ostrovsky
Format: Article
Language:Russian
Published: Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2023-03-01
Series:Регуляторные исследования и экспертиза лекарственных средств
Subjects:
dna damage
comet assay
kappa-opioid receptor agonists
benzimidazole derivatives
analgesics
preclinical studies
Online Access:https://www.vedomostincesmp.ru/jour/article/view/526
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