Effects of fixed-dose indapamide/perindopril combination on arterial function in patients with hypertension and chronic kidney disease: key results of the CAMERTON program
Aim. To study the effects of fixed-dose indapamide/perindopril combination on endothelial function and arterial stiffness in patients with uncontrolled stage 1-2 hypertension (HTN) and chronic kidney disease (CKD).Material and methods. Total of 100 patients with uncured or uncontrolled with ≥3 month...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2019-12-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3620 |
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| author | Zh. D. Kobalava V. V. Kireeva V. S. Chernomorets E. A. Troitskaya Yu. V. Stavtseva |
| author_facet | Zh. D. Kobalava V. V. Kireeva V. S. Chernomorets E. A. Troitskaya Yu. V. Stavtseva |
| author_sort | Zh. D. Kobalava |
| collection | DOAJ |
| description | Aim. To study the effects of fixed-dose indapamide/perindopril combination on endothelial function and arterial stiffness in patients with uncontrolled stage 1-2 hypertension (HTN) and chronic kidney disease (CKD).Material and methods. Total of 100 patients with uncured or uncontrolled with ≥3 months antihypertensive therapy HTN and CKD G3 (67% females, mean age 59,1±12,5 years) were included in the study. Each patient took indapamide/perindop combination in accordance with 1 of 3 existing regimes (depending on doses) for 3 months. Primary aim was to assess the effects of indapamide/perindopril combination on endothelial function and parameters of arterial stiffness after 12 weeks of treatment (assessment by AngioScan diagnostic complex). Secondary aims were achievement of target blood pressure (BP) after 4 and 12 weeks of therapy and assessment of glomerular filtration rate (GFR) and the albumin-tocreatinine ratio (ACR) changes after 12 weeks.Results. Initially, there was an increase in arterial stiffness parameters in all patients, and during treatment decrease was observed: central systolic BP (SBP) from 120±10,1 to 112,9±6,3 mm Hg, median augmentation index from 10,9% to 4,6%, stiffness index from 8,1±2,4 to 7,1±0,9, vascular age decreased by 9,6% (р< 0,001 for trend). Significant improvement of endothelial function was observed regardless of diabetes presence: occlusion index increased from 1,5±0,3 to 1,7±0,5, median phase shift — from -4,6 to -2,4 ms (p< 0,01). After 4 weeks, 27% of patients reached target BP, by the end of the study — 90%. A decrease in the median ACR from 16,3 to 15,0 mg/g, GFR increase from 50,2±7,6 to 53,6±8,7 ml/min/1,73 m2 were observed (p< 0,01 for trend).Conclusion. Therapy with a fixed-dose indapamide/perindopril combination in patients with uncontrolled stage 1-2 HTN and G3 CKD leads to a significant improvement in arterial stiffness, endothelial and renal function, and achievement of target BP in 90% of patients. |
| format | Article |
| id | doaj-art-bc81b51a1c6c4137a14a0dae9c2b68f7 |
| institution | Matheson Library |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-bc81b51a1c6c4137a14a0dae9c2b68f72025-08-04T13:00:21Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202019-12-01012879510.15829/1560-4071-2019-12-87-952805Effects of fixed-dose indapamide/perindopril combination on arterial function in patients with hypertension and chronic kidney disease: key results of the CAMERTON programZh. D. Kobalava0V. V. Kireeva1V. S. Chernomorets2E. A. Troitskaya3Yu. V. Stavtseva4The Peoples’ Friendship University of RussiaResearch Center HospitalThe Peoples’ Friendship University of RussiaThe Peoples’ Friendship University of RussiaThe Peoples’ Friendship University of RussiaAim. To study the effects of fixed-dose indapamide/perindopril combination on endothelial function and arterial stiffness in patients with uncontrolled stage 1-2 hypertension (HTN) and chronic kidney disease (CKD).Material and methods. Total of 100 patients with uncured or uncontrolled with ≥3 months antihypertensive therapy HTN and CKD G3 (67% females, mean age 59,1±12,5 years) were included in the study. Each patient took indapamide/perindop combination in accordance with 1 of 3 existing regimes (depending on doses) for 3 months. Primary aim was to assess the effects of indapamide/perindopril combination on endothelial function and parameters of arterial stiffness after 12 weeks of treatment (assessment by AngioScan diagnostic complex). Secondary aims were achievement of target blood pressure (BP) after 4 and 12 weeks of therapy and assessment of glomerular filtration rate (GFR) and the albumin-tocreatinine ratio (ACR) changes after 12 weeks.Results. Initially, there was an increase in arterial stiffness parameters in all patients, and during treatment decrease was observed: central systolic BP (SBP) from 120±10,1 to 112,9±6,3 mm Hg, median augmentation index from 10,9% to 4,6%, stiffness index from 8,1±2,4 to 7,1±0,9, vascular age decreased by 9,6% (р< 0,001 for trend). Significant improvement of endothelial function was observed regardless of diabetes presence: occlusion index increased from 1,5±0,3 to 1,7±0,5, median phase shift — from -4,6 to -2,4 ms (p< 0,01). After 4 weeks, 27% of patients reached target BP, by the end of the study — 90%. A decrease in the median ACR from 16,3 to 15,0 mg/g, GFR increase from 50,2±7,6 to 53,6±8,7 ml/min/1,73 m2 were observed (p< 0,01 for trend).Conclusion. Therapy with a fixed-dose indapamide/perindopril combination in patients with uncontrolled stage 1-2 HTN and G3 CKD leads to a significant improvement in arterial stiffness, endothelial and renal function, and achievement of target BP in 90% of patients.https://russjcardiol.elpub.ru/jour/article/view/3620hypertensionchronic kidney diseasefixed-dose combinationindapamide/perindoprilarterial stiffnessendothelial function |
| spellingShingle | Zh. D. Kobalava V. V. Kireeva V. S. Chernomorets E. A. Troitskaya Yu. V. Stavtseva Effects of fixed-dose indapamide/perindopril combination on arterial function in patients with hypertension and chronic kidney disease: key results of the CAMERTON program Российский кардиологический журнал hypertension chronic kidney disease fixed-dose combination indapamide/perindopril arterial stiffness endothelial function |
| title | Effects of fixed-dose indapamide/perindopril combination on arterial function in patients with hypertension and chronic kidney disease: key results of the CAMERTON program |
| title_full | Effects of fixed-dose indapamide/perindopril combination on arterial function in patients with hypertension and chronic kidney disease: key results of the CAMERTON program |
| title_fullStr | Effects of fixed-dose indapamide/perindopril combination on arterial function in patients with hypertension and chronic kidney disease: key results of the CAMERTON program |
| title_full_unstemmed | Effects of fixed-dose indapamide/perindopril combination on arterial function in patients with hypertension and chronic kidney disease: key results of the CAMERTON program |
| title_short | Effects of fixed-dose indapamide/perindopril combination on arterial function in patients with hypertension and chronic kidney disease: key results of the CAMERTON program |
| title_sort | effects of fixed dose indapamide perindopril combination on arterial function in patients with hypertension and chronic kidney disease key results of the camerton program |
| topic | hypertension chronic kidney disease fixed-dose combination indapamide/perindopril arterial stiffness endothelial function |
| url | https://russjcardiol.elpub.ru/jour/article/view/3620 |
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