Transcriptome-guided engineering of a native niacin transporter in Lactiplantibacillus plantarum unveils metabolic rewiring for NMN biosynthesis

Introductionβ-nicotinamide mononucleotide (NMN), a precursor of NAD+, holds promise as a functional food ingredient for mitigating age-related decline. This study enhanced NMN biosynthesis in probiotic Lactiplantibacillus plantarum.MethodsA putative niacin transporter, lp2514, was identified via mol...

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Bibliographic Details
Main Authors: Linghui Kong, Xinyu Li, Qing He, Qingshou Yao, Lianzhong Ai, Jiayang Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Microbiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1637666/full
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