In Vitro and In Silico Assessments of Curcuminoids and Turmerones from <i>Curcuma longa</i> as Novel Inhibitors of <i>Leishmania infantum</i> Arginase

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In Vitro and In Silico Assessments of Curcuminoids and Turmerones from <i>Curcuma longa</i> as Novel Inhibitors of <i>Leishmania infantum</i> Arginase

<b>Background/Objectives</b>: The anti-<i>Leishmania</i> potential of <i>Curcuma longa</i> and its derivatives, such as curcuminoids, is well-established, yet their mechanisms of action remain underexplored. This study investigates the inhibitory effects of <i&...

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Bibliographic Details
Main Authors:	Flora F. S. Spíndola, Anderson S. Pinheiro, Maria Athana Mpalantinos, Jefferson R. A. Silva, Walter S. M. F. Neto, Raissa A. Conceição, Eduarda M. Barreto, Barbara A. Abrahim-Vieira, Carlos R. Rodrigues, Alessandra M. T. Souza, Dirlei Nico, Ana Claudia F. Amaral, Andreza R. Garcia, Igor A. Rodrigues
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Pharmaceuticals
Subjects:	antileishmanial curcumin turmerone ADMET molecular docking enzymatic inhibition
Online Access:	https://www.mdpi.com/1424-8247/18/6/851
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