Dapagliflozin and Silymarin Ameliorate Cisplatin-Induced Nephrotoxicity via Nrf2/HO-1 Upregulation: A Preclinical Mechanistic Study

Dapagliflozin and Silymarin Ameliorate Cisplatin-Induced Nephrotoxicity via Nrf2/HO-1 Upregulation: A Preclinical Mechanistic Study

This study evaluated the nephroprotective potential of dapagliflozin and silymarin, alone and in combination, against cisplatin-induced kidney damage in female Wistar rats. Cisplatin was administered at 3 mg/kg weekly to all groups except the normal controls, with treatments of silymarin (50 mg/kg/d...

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Bibliographic Details
Main Authors: Shakta Mani Satyam, Laxminarayana Kurady Bairy, Abdul Rehman, Anuradha Asokan Nair, Mohamed Farook, Nirmal Nachiketh Binu, Sofiya Khan, Mohamed Yehya, Mohammed Moin Khan
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Sci
Subjects:
sodium-glucose transporter protein-2 inhibitors
chemotherapy
chemo protectant
cancer
chronic kidney disease
repurposing drugs
Online Access:https://www.mdpi.com/2413-4155/7/2/59
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