Impact of multifactorial interventions with medication and lifestyle optimization on patients with type 2 diabetes: A randomised controlled trial.
<h4>Background</h4>Clinical evidence on the protective effects of a balanced diet, exercise, and medication adherence along with intensive glucose-lowering therapies on diabetes progression is lacking, and interventions that are most effective in slowing cardiorenal metabolic complicatio...
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Public Library of Science (PLoS)
2025-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0327211 |
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| author | Marwan El-Deyarbi Luai Ahmed Jeffrey King Zelal S Adi Ahmed Al Juboori Nirmin A Mansour Huda Al Nuaimi Rami Beiram Salahdein Aburuz |
| author_facet | Marwan El-Deyarbi Luai Ahmed Jeffrey King Zelal S Adi Ahmed Al Juboori Nirmin A Mansour Huda Al Nuaimi Rami Beiram Salahdein Aburuz |
| author_sort | Marwan El-Deyarbi |
| collection | DOAJ |
| description | <h4>Background</h4>Clinical evidence on the protective effects of a balanced diet, exercise, and medication adherence along with intensive glucose-lowering therapies on diabetes progression is lacking, and interventions that are most effective in slowing cardiorenal metabolic complications in patients with diabetes remain unelucidated.<h4>Objective</h4>To determine the effects of long-term multifactorial interventions on clinical outcomes in Emirati patients with diabetes attending ambulatory healthcare clinics.<h4>Methods</h4>We conducted a randomised controlled clinical trial at the Oud Al-Touba Clinic involving 192 participants with diabetes, who were blinded to the intervention and control groups, and followed up for 1 year. At the 3-, 6-, and 9-month visits, the intervention and control groups received multifactorial interventions and standard routine care, respectively. Glycated haemoglobin A1c (HbA1c) levels, estimated glomerular filtration rate (eGFR), blood pressure, electrolyte levels, and cardiovascular events were assessed at study completion.<h4>Results</h4>During a mean follow-up of 11.9 months, 40.4% of the participants in the intervention group (31.6% in the control group) achieved diabetes control (HbA1c < 7%), with a significant mean difference of -0.36% in HbA1c levels between the groups (95% CI: -0.54 - -0.19, P < 0.01). Participants in the multifactorial group achieved a significant mean difference in low-density lipoprotein cholesterol levels (mean difference = -0.14, 95% CI: -0.27-0.001, P < 0.03), and significant adjusted mean difference of eGFR levels difference (3.93 mL/min/1.73 m2, 95% CI: 1.27-6.58, P < 0.01) at study completion compared to those in the control group. Moreover, the percentage of participants in the intervention group who met the blood pressure target increased from 38.3% to 51.1%, accompanied with a decrease in serum electrolyte levels, compared to 34.7% to 36.7% in the control group at the end of the follow-up.<h4>Conclusions</h4>Implementing multifactorial interventions by a multidisciplinary team improved several clinical manifestations, including HbA1c, SBP, and eGFR, and decreased cardiovascular risk factors despite the decreased diabetes medication use.<h4>Trial registration</h4>ClinicalTrials.gov NCT04942119. |
| format | Article |
| id | doaj-art-b9f55fbf6dc3493e844ffa2e89512ed6 |
| institution | Matheson Library |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-b9f55fbf6dc3493e844ffa2e89512ed62025-07-14T05:31:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01207e032721110.1371/journal.pone.0327211Impact of multifactorial interventions with medication and lifestyle optimization on patients with type 2 diabetes: A randomised controlled trial.Marwan El-DeyarbiLuai AhmedJeffrey KingZelal S AdiAhmed Al JubooriNirmin A MansourHuda Al NuaimiRami BeiramSalahdein Aburuz<h4>Background</h4>Clinical evidence on the protective effects of a balanced diet, exercise, and medication adherence along with intensive glucose-lowering therapies on diabetes progression is lacking, and interventions that are most effective in slowing cardiorenal metabolic complications in patients with diabetes remain unelucidated.<h4>Objective</h4>To determine the effects of long-term multifactorial interventions on clinical outcomes in Emirati patients with diabetes attending ambulatory healthcare clinics.<h4>Methods</h4>We conducted a randomised controlled clinical trial at the Oud Al-Touba Clinic involving 192 participants with diabetes, who were blinded to the intervention and control groups, and followed up for 1 year. At the 3-, 6-, and 9-month visits, the intervention and control groups received multifactorial interventions and standard routine care, respectively. Glycated haemoglobin A1c (HbA1c) levels, estimated glomerular filtration rate (eGFR), blood pressure, electrolyte levels, and cardiovascular events were assessed at study completion.<h4>Results</h4>During a mean follow-up of 11.9 months, 40.4% of the participants in the intervention group (31.6% in the control group) achieved diabetes control (HbA1c < 7%), with a significant mean difference of -0.36% in HbA1c levels between the groups (95% CI: -0.54 - -0.19, P < 0.01). Participants in the multifactorial group achieved a significant mean difference in low-density lipoprotein cholesterol levels (mean difference = -0.14, 95% CI: -0.27-0.001, P < 0.03), and significant adjusted mean difference of eGFR levels difference (3.93 mL/min/1.73 m2, 95% CI: 1.27-6.58, P < 0.01) at study completion compared to those in the control group. Moreover, the percentage of participants in the intervention group who met the blood pressure target increased from 38.3% to 51.1%, accompanied with a decrease in serum electrolyte levels, compared to 34.7% to 36.7% in the control group at the end of the follow-up.<h4>Conclusions</h4>Implementing multifactorial interventions by a multidisciplinary team improved several clinical manifestations, including HbA1c, SBP, and eGFR, and decreased cardiovascular risk factors despite the decreased diabetes medication use.<h4>Trial registration</h4>ClinicalTrials.gov NCT04942119.https://doi.org/10.1371/journal.pone.0327211 |
| spellingShingle | Marwan El-Deyarbi Luai Ahmed Jeffrey King Zelal S Adi Ahmed Al Juboori Nirmin A Mansour Huda Al Nuaimi Rami Beiram Salahdein Aburuz Impact of multifactorial interventions with medication and lifestyle optimization on patients with type 2 diabetes: A randomised controlled trial. PLoS ONE |
| title | Impact of multifactorial interventions with medication and lifestyle optimization on patients with type 2 diabetes: A randomised controlled trial. |
| title_full | Impact of multifactorial interventions with medication and lifestyle optimization on patients with type 2 diabetes: A randomised controlled trial. |
| title_fullStr | Impact of multifactorial interventions with medication and lifestyle optimization on patients with type 2 diabetes: A randomised controlled trial. |
| title_full_unstemmed | Impact of multifactorial interventions with medication and lifestyle optimization on patients with type 2 diabetes: A randomised controlled trial. |
| title_short | Impact of multifactorial interventions with medication and lifestyle optimization on patients with type 2 diabetes: A randomised controlled trial. |
| title_sort | impact of multifactorial interventions with medication and lifestyle optimization on patients with type 2 diabetes a randomised controlled trial |
| url | https://doi.org/10.1371/journal.pone.0327211 |
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