Exp erimental research of wearable artificial kidney
Aim. The article presents the results of wearable artificial kidney (WAK) biomedical trial based on peritoneal dialysis with continuous dialysate regeneration.Materials and methods. The trial was carried out on a 15-kg dog. First stage: dialysis was carried out on healthy dog to evaluate effect of W...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2017-09-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/780 |
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| author | N. A. Bazaev V. M. Grinvald S. V. Selishchev A. V. Kalinov A. V. Kozachuk V. V. Kosatkin F. F. Tyunder D. V. Federyakin |
| author_facet | N. A. Bazaev V. M. Grinvald S. V. Selishchev A. V. Kalinov A. V. Kozachuk V. V. Kosatkin F. F. Tyunder D. V. Federyakin |
| author_sort | N. A. Bazaev |
| collection | DOAJ |
| description | Aim. The article presents the results of wearable artificial kidney (WAK) biomedical trial based on peritoneal dialysis with continuous dialysate regeneration.Materials and methods. The trial was carried out on a 15-kg dog. First stage: dialysis was carried out on healthy dog to evaluate effect of WAK on blood biochemical indicators. Second stage: 200 ml of X-ray contrast agent was injected into dog’s bloodstream to simulate acute kidney failure.Results. During trial (39.5 hours) WAK was performing continuous peritoneal dialysis with dialysis fluid regeneration. During second stage (34 hours) creatinine and uric acid were eliminated from dialysis solution at the rate of 0.3 mg/h, urea was eliminated at the rate of 0.15 g/h, total removed ultrafiltrate volume was 350 ml. At the end of the second stage blood biochemical indicators stabilised in the range of normal values.Conclusion. Developed WAK can perform continuous blood purification and ultrafiltration with no pathologic impact on blood biochemical indicators. |
| format | Article |
| id | doaj-art-b9dff38cad5b4c82b0f9fbe391da0617 |
| institution | Matheson Library |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2017-09-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-b9dff38cad5b4c82b0f9fbe391da06172025-08-04T14:02:08ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912017-09-01193465210.15825/1995-1191-2017-3-46-52644Exp erimental research of wearable artificial kidneyN. A. Bazaev0V. M. Grinvald1S. V. Selishchev2A. V. Kalinov3A. V. Kozachuk4V. V. Kosatkin5F. F. Tyunder6D. V. Federyakin7National Research University of Electronic Technology «MIET»National Research University of Electronic Technology «MIET»National Research University of Electronic Technology «MIET»Tver State Medical UniversityTver State Medical UniversityRegional Clinical HospitalN.A. Semashko Central Clinical Hospital 2 of JSC Russian RailwaysTver State Medical UniversityAim. The article presents the results of wearable artificial kidney (WAK) biomedical trial based on peritoneal dialysis with continuous dialysate regeneration.Materials and methods. The trial was carried out on a 15-kg dog. First stage: dialysis was carried out on healthy dog to evaluate effect of WAK on blood biochemical indicators. Second stage: 200 ml of X-ray contrast agent was injected into dog’s bloodstream to simulate acute kidney failure.Results. During trial (39.5 hours) WAK was performing continuous peritoneal dialysis with dialysis fluid regeneration. During second stage (34 hours) creatinine and uric acid were eliminated from dialysis solution at the rate of 0.3 mg/h, urea was eliminated at the rate of 0.15 g/h, total removed ultrafiltrate volume was 350 ml. At the end of the second stage blood biochemical indicators stabilised in the range of normal values.Conclusion. Developed WAK can perform continuous blood purification and ultrafiltration with no pathologic impact on blood biochemical indicators.https://journal.transpl.ru/vtio/article/view/780wearable artificial kidneycontinuous peritoneal dialysis with dialysis fluid regenerationbiomedical trial |
| spellingShingle | N. A. Bazaev V. M. Grinvald S. V. Selishchev A. V. Kalinov A. V. Kozachuk V. V. Kosatkin F. F. Tyunder D. V. Federyakin Exp erimental research of wearable artificial kidney Вестник трансплантологии и искусственных органов wearable artificial kidney continuous peritoneal dialysis with dialysis fluid regeneration biomedical trial |
| title | Exp erimental research of wearable artificial kidney |
| title_full | Exp erimental research of wearable artificial kidney |
| title_fullStr | Exp erimental research of wearable artificial kidney |
| title_full_unstemmed | Exp erimental research of wearable artificial kidney |
| title_short | Exp erimental research of wearable artificial kidney |
| title_sort | exp erimental research of wearable artificial kidney |
| topic | wearable artificial kidney continuous peritoneal dialysis with dialysis fluid regeneration biomedical trial |
| url | https://journal.transpl.ru/vtio/article/view/780 |
| work_keys_str_mv | AT nabazaev experimentalresearchofwearableartificialkidney AT vmgrinvald experimentalresearchofwearableartificialkidney AT svselishchev experimentalresearchofwearableartificialkidney AT avkalinov experimentalresearchofwearableartificialkidney AT avkozachuk experimentalresearchofwearableartificialkidney AT vvkosatkin experimentalresearchofwearableartificialkidney AT fftyunder experimentalresearchofwearableartificialkidney AT dvfederyakin experimentalresearchofwearableartificialkidney |