VARIABILITY AND microRNA EXPRESSION LEVEL IN TISSUES OF HEAD AND NECK TUMORS
Small non-coding RNAs (miRNAs) are not only an important regulator of gene expression by participating in almost all basic processes in the cell, but are specific molecules and can be used for many applications in clinical diagnostics. In our study, we assessed the level of miRNA expression in tumor...
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/40 |
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| author | Е. G. Nikitina L. N. Urazova О. V. Cheremisina D. Е. Kulbakin S. N. Stegniy |
| author_facet | Е. G. Nikitina L. N. Urazova О. V. Cheremisina D. Е. Kulbakin S. N. Stegniy |
| author_sort | Е. G. Nikitina |
| collection | DOAJ |
| description | Small non-coding RNAs (miRNAs) are not only an important regulator of gene expression by participating in almost all basic processes in the cell, but are specific molecules and can be used for many applications in clinical diagnostics. In our study, we assessed the level of miRNA expression in tumor tissue of patients with head and neck tumors of various sites. New data regarding the expression pattern of eight miRNAs in tumor tissue from patients with cancer of the larynx, tongue and papillary thyroid carcinoma, namely: miR-18a, -21, -155, -200a, -200c, -205, -221 and -494 were obtained. The spectrum of miRNA-specific localizations was analyzed, suggesting the existence of differences in the mechanisms of participation of the same miRNA in carcinogenesis of tumors of different epitopes of the head and neck. The panel of miR-200a, -200c, -21 and -205 was shown to be specific for determining the two locations (laryngeal and thyroid cancers) and probably can be used to define the site of a secondary tumor and / or metastasis of unknown origin. |
| format | Article |
| id | doaj-art-b95c4eb9ba6b4ce4b52d0d6d5d9cc942 |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-b95c4eb9ba6b4ce4b52d0d6d5d9cc9422025-08-04T10:33:34ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-0103283340VARIABILITY AND microRNA EXPRESSION LEVEL IN TISSUES OF HEAD AND NECK TUMORSЕ. G. Nikitina0L. N. Urazova1О. V. Cheremisina2D. Е. Kulbakin3S. N. Stegniy4Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk National Research Tomsk State University, TomskCancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, TomskCancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, TomskCancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk National Research Tomsk State University, TomskNational Research Tomsk State University, TomskSmall non-coding RNAs (miRNAs) are not only an important regulator of gene expression by participating in almost all basic processes in the cell, but are specific molecules and can be used for many applications in clinical diagnostics. In our study, we assessed the level of miRNA expression in tumor tissue of patients with head and neck tumors of various sites. New data regarding the expression pattern of eight miRNAs in tumor tissue from patients with cancer of the larynx, tongue and papillary thyroid carcinoma, namely: miR-18a, -21, -155, -200a, -200c, -205, -221 and -494 were obtained. The spectrum of miRNA-specific localizations was analyzed, suggesting the existence of differences in the mechanisms of participation of the same miRNA in carcinogenesis of tumors of different epitopes of the head and neck. The panel of miR-200a, -200c, -21 and -205 was shown to be specific for determining the two locations (laryngeal and thyroid cancers) and probably can be used to define the site of a secondary tumor and / or metastasis of unknown origin.https://www.siboncoj.ru/jour/article/view/40head and neck tumorsmirna |
| spellingShingle | Е. G. Nikitina L. N. Urazova О. V. Cheremisina D. Е. Kulbakin S. N. Stegniy VARIABILITY AND microRNA EXPRESSION LEVEL IN TISSUES OF HEAD AND NECK TUMORS Сибирский онкологический журнал head and neck tumors mirna |
| title | VARIABILITY AND microRNA EXPRESSION LEVEL IN TISSUES OF HEAD AND NECK TUMORS |
| title_full | VARIABILITY AND microRNA EXPRESSION LEVEL IN TISSUES OF HEAD AND NECK TUMORS |
| title_fullStr | VARIABILITY AND microRNA EXPRESSION LEVEL IN TISSUES OF HEAD AND NECK TUMORS |
| title_full_unstemmed | VARIABILITY AND microRNA EXPRESSION LEVEL IN TISSUES OF HEAD AND NECK TUMORS |
| title_short | VARIABILITY AND microRNA EXPRESSION LEVEL IN TISSUES OF HEAD AND NECK TUMORS |
| title_sort | variability and microrna expression level in tissues of head and neck tumors |
| topic | head and neck tumors mirna |
| url | https://www.siboncoj.ru/jour/article/view/40 |
| work_keys_str_mv | AT egnikitina variabilityandmicrornaexpressionlevelintissuesofheadandnecktumors AT lnurazova variabilityandmicrornaexpressionlevelintissuesofheadandnecktumors AT ovcheremisina variabilityandmicrornaexpressionlevelintissuesofheadandnecktumors AT dekulbakin variabilityandmicrornaexpressionlevelintissuesofheadandnecktumors AT snstegniy variabilityandmicrornaexpressionlevelintissuesofheadandnecktumors |