Septic Pulmonary Embolism in a Patient with Generalized Salmonellosis: a Clinical Case and Meta-Analysis
Nontyphoid Salmonella are gram-negative bacteria that induce Th1-mediated immunity. They rarely lead to a generalized infection, primarily developing in immunocompromised patients with cellular immunity defects. Septic pulmonary embolism is also a rare condition in which emboli contain microorganism...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-12-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/764 |
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| author | A. D. Strutynskaya M. A. Karnaushkina I. E. Tyurin M. P. Suvorova S. V. Yakovlev |
| author_facet | A. D. Strutynskaya M. A. Karnaushkina I. E. Tyurin M. P. Suvorova S. V. Yakovlev |
| author_sort | A. D. Strutynskaya |
| collection | DOAJ |
| description | Nontyphoid Salmonella are gram-negative bacteria that induce Th1-mediated immunity. They rarely lead to a generalized infection, primarily developing in immunocompromised patients with cellular immunity defects. Septic pulmonary embolism is also a rare condition in which emboli contain microorganisms from extrapulmonary infective foci. The article presents a rare clinical case of a patient with pulmonary embolism and generalized nontyphoid salmonellosis due to the presence of Asp299Gly and Thr399Ile genetic polymorphisms in the TLR4 gene. Such a defect of cell-mediated immunity was a trigger for destructive changes in the lung parenchyma, prothrombotic state, and generalization of the infectious process. |
| format | Article |
| id | doaj-art-b8a965e5d81c40e8a93977a0dca29724 |
| institution | Matheson Library |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-b8a965e5d81c40e8a93977a0dca297242025-08-03T13:04:48ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-12-01659-10374310.37489/0235-2990-2020-65-9-10-37-43749Septic Pulmonary Embolism in a Patient with Generalized Salmonellosis: a Clinical Case and Meta-AnalysisA. D. Strutynskaya0M. A. Karnaushkina1I. E. Tyurin2M. P. Suvorova3S. V. Yakovlev4National Medical Research Center for Children-s HealthI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationRussian Medical Academy of Postgraduate EducationI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationNontyphoid Salmonella are gram-negative bacteria that induce Th1-mediated immunity. They rarely lead to a generalized infection, primarily developing in immunocompromised patients with cellular immunity defects. Septic pulmonary embolism is also a rare condition in which emboli contain microorganisms from extrapulmonary infective foci. The article presents a rare clinical case of a patient with pulmonary embolism and generalized nontyphoid salmonellosis due to the presence of Asp299Gly and Thr399Ile genetic polymorphisms in the TLR4 gene. Such a defect of cell-mediated immunity was a trigger for destructive changes in the lung parenchyma, prothrombotic state, and generalization of the infectious process.https://www.antibiotics-chemotherapy.ru/jour/article/view/764salmonellosispulmonary embolismsepsispolymorphismgenetlr4immunityclinical picture |
| spellingShingle | A. D. Strutynskaya M. A. Karnaushkina I. E. Tyurin M. P. Suvorova S. V. Yakovlev Septic Pulmonary Embolism in a Patient with Generalized Salmonellosis: a Clinical Case and Meta-Analysis Антибиотики и Химиотерапия salmonellosis pulmonary embolism sepsis polymorphism gene tlr4 immunity clinical picture |
| title | Septic Pulmonary Embolism in a Patient with Generalized Salmonellosis: a Clinical Case and Meta-Analysis |
| title_full | Septic Pulmonary Embolism in a Patient with Generalized Salmonellosis: a Clinical Case and Meta-Analysis |
| title_fullStr | Septic Pulmonary Embolism in a Patient with Generalized Salmonellosis: a Clinical Case and Meta-Analysis |
| title_full_unstemmed | Septic Pulmonary Embolism in a Patient with Generalized Salmonellosis: a Clinical Case and Meta-Analysis |
| title_short | Septic Pulmonary Embolism in a Patient with Generalized Salmonellosis: a Clinical Case and Meta-Analysis |
| title_sort | septic pulmonary embolism in a patient with generalized salmonellosis a clinical case and meta analysis |
| topic | salmonellosis pulmonary embolism sepsis polymorphism gene tlr4 immunity clinical picture |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/764 |
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