Influence of pulsating intracardiac blood flow on radiofrequency catheter ablation outcomes in an anatomy-based atrium model
Background Highly consistent cardiac ablation outcomes through radiofrequency catheter ablation (RFCA) under pulsatile and constant flow profiles (PP&CP) of intracardiac blood were previously indicated by computer modeling, with simplified geometry and lossless receipt of inflow for ablation cat...
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Taylor & Francis Group
2022-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2022.2108149 |
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| author | Kaihao Gu Shengjie Yan Xiaomei Wu |
| author_facet | Kaihao Gu Shengjie Yan Xiaomei Wu |
| author_sort | Kaihao Gu |
| collection | DOAJ |
| description | Background Highly consistent cardiac ablation outcomes through radiofrequency catheter ablation (RFCA) under pulsatile and constant flow profiles (PP&CP) of intracardiac blood were previously indicated by computer modeling, with simplified geometry and lossless receipt of inflow for ablation catheters. This study aimed to further investigate the effects of intracardiac blood pulsatility in an anatomy-based atrium model.Methods Four pulmonary veins were blood inflows at 10 mm Hg. The mitral valve was the outflow, with PP based on pulsatile velocity curve from clinical measurements, and CP was obtained by averaging the velocity curve under PP over an ablation time of 30 s. A numerical comparison between ablation results under PP and CP, without experimental validation, was performed.Results Temperature fluctuations persisted in mid-myocardium, and most clearly in blood and endocardium under PP. At a constant power of 20 W, marked differences in ablation outcome between PP and CP occurred in the middle of unilateral pulmonary veins and the posterior wall of the left atrium (LA) where the blood velocities were significantly decreased under CP. The mid-myocardial, blood and endocardial temperatures, as well as the effective lesion volume at the former position, were decreased by 4.1%, 15%, 13.6%, and 13.8%, respectively under PP. The extents for the latter position were 11%, 22%, 22.5%, and 55.6%, respectively.Conclusion Intracardiac flow pulsatility causes a greater reduction in blood and endocardial temperatures at ablation sites away from the main bloodstream, effective cooling of which is more likely to rely on blood velocities approaching peak PP values. |
| format | Article |
| id | doaj-art-b814b724b32e48a9aeeab417eb0128b5 |
| institution | Matheson Library |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-b814b724b32e48a9aeeab417eb0128b52025-07-21T16:16:05ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572022-12-013911064107710.1080/02656736.2022.2108149Influence of pulsating intracardiac blood flow on radiofrequency catheter ablation outcomes in an anatomy-based atrium modelKaihao Gu0Shengjie Yan1Xiaomei Wu2Centre for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, ChinaCentre for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, ChinaCentre for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, ChinaBackground Highly consistent cardiac ablation outcomes through radiofrequency catheter ablation (RFCA) under pulsatile and constant flow profiles (PP&CP) of intracardiac blood were previously indicated by computer modeling, with simplified geometry and lossless receipt of inflow for ablation catheters. This study aimed to further investigate the effects of intracardiac blood pulsatility in an anatomy-based atrium model.Methods Four pulmonary veins were blood inflows at 10 mm Hg. The mitral valve was the outflow, with PP based on pulsatile velocity curve from clinical measurements, and CP was obtained by averaging the velocity curve under PP over an ablation time of 30 s. A numerical comparison between ablation results under PP and CP, without experimental validation, was performed.Results Temperature fluctuations persisted in mid-myocardium, and most clearly in blood and endocardium under PP. At a constant power of 20 W, marked differences in ablation outcome between PP and CP occurred in the middle of unilateral pulmonary veins and the posterior wall of the left atrium (LA) where the blood velocities were significantly decreased under CP. The mid-myocardial, blood and endocardial temperatures, as well as the effective lesion volume at the former position, were decreased by 4.1%, 15%, 13.6%, and 13.8%, respectively under PP. The extents for the latter position were 11%, 22%, 22.5%, and 55.6%, respectively.Conclusion Intracardiac flow pulsatility causes a greater reduction in blood and endocardial temperatures at ablation sites away from the main bloodstream, effective cooling of which is more likely to rely on blood velocities approaching peak PP values.https://www.tandfonline.com/doi/10.1080/02656736.2022.2108149Ablation characteristicsanatomy-based atrium modelblood pulsatilityfinite-element methodradiofrequency catheter ablation |
| spellingShingle | Kaihao Gu Shengjie Yan Xiaomei Wu Influence of pulsating intracardiac blood flow on radiofrequency catheter ablation outcomes in an anatomy-based atrium model International Journal of Hyperthermia Ablation characteristics anatomy-based atrium model blood pulsatility finite-element method radiofrequency catheter ablation |
| title | Influence of pulsating intracardiac blood flow on radiofrequency catheter ablation outcomes in an anatomy-based atrium model |
| title_full | Influence of pulsating intracardiac blood flow on radiofrequency catheter ablation outcomes in an anatomy-based atrium model |
| title_fullStr | Influence of pulsating intracardiac blood flow on radiofrequency catheter ablation outcomes in an anatomy-based atrium model |
| title_full_unstemmed | Influence of pulsating intracardiac blood flow on radiofrequency catheter ablation outcomes in an anatomy-based atrium model |
| title_short | Influence of pulsating intracardiac blood flow on radiofrequency catheter ablation outcomes in an anatomy-based atrium model |
| title_sort | influence of pulsating intracardiac blood flow on radiofrequency catheter ablation outcomes in an anatomy based atrium model |
| topic | Ablation characteristics anatomy-based atrium model blood pulsatility finite-element method radiofrequency catheter ablation |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2022.2108149 |
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