Beyond language: empathy and emotion recognition deficits in primary progressive aphasias
Although primary progressive aphasia (PPA) is considered a language disorder, increasing evidence points to the presence of social cognition impairments in PPA variants. The aims of this study were to explore empathy and emotion recognition deficits in the three PPA variants (sv-PPA, lv-PPA, nfv-PPA...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158225001226 |
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| author | Giulia Giacomucci Alice Pieri Valentina Moschini Chiara Crucitti Sonia Padiglioni Carmen Morinelli Giulia Galdo Filippo Emiliani Matilde Nerattini Silvia Bagnoli Assunta Ingannato Sandro Sorbi Benedetta Nacmias Valentina Berti Valentina Bessi |
| author_facet | Giulia Giacomucci Alice Pieri Valentina Moschini Chiara Crucitti Sonia Padiglioni Carmen Morinelli Giulia Galdo Filippo Emiliani Matilde Nerattini Silvia Bagnoli Assunta Ingannato Sandro Sorbi Benedetta Nacmias Valentina Berti Valentina Bessi |
| author_sort | Giulia Giacomucci |
| collection | DOAJ |
| description | Although primary progressive aphasia (PPA) is considered a language disorder, increasing evidence points to the presence of social cognition impairments in PPA variants. The aims of this study were to explore empathy and emotion recognition deficits in the three PPA variants (sv-PPA, lv-PPA, nfv-PPA) and to identify their neural correlates.Eleven sv-PPA, 34 lv-PPA,11 nfv-PPA patients and 34 healthy controls (HC) were included in this study. Empathy was explored with the Interpersonal Reactivity Index (IRI) (Perspective Taking – PT, Fantasy – FT, Empathic Concern – EC, Personal Distress – PD), rated by caregivers before (T0) and after (T1) the onset of cognitive symptoms. Emotion recognition was evaluated with the Ekman 60Faces (EK-60F) Test and metabolic activity with [18F]FDG-PET.In all PPA variants, PT score was reduced from T0 to T1 (sv-PPA p = 0.014, lv-PPA p < 0.001, nfv-PPA p = 0.022) and PD score was increased (sv-PPA p = 0.033, lv-PPA p < 0.001, nfv-PPA p = 0.009). Only lv-PPA showed a decrease of FT score (p = 0.024), while EC was spared in all three variants. Sv-PPA patients had the worst performances in the EK-60F Test, followed by lv-PPA and, lastly, by nfv-PPA.Correlations between EK-60F scores and metabolic activity were found in sv-PPA and lv-PPA, highlighting the involvement of areas participating in the emotion recognition network: cingulate cortex, insula, temporal and orbitofrontal cortices and inferior frontal gyrus.All PPA variants exhibited impairments in cognitive empathy (PT) and heightened emotional contagion (PD). The most severe deficits in emotion recognition were shown by sv-PPA, while nfv-PPA was the less impaired variant. |
| format | Article |
| id | doaj-art-b6fcf9f1b804423e96a4849e1c1c0dfd |
| institution | Matheson Library |
| issn | 2213-1582 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj-art-b6fcf9f1b804423e96a4849e1c1c0dfd2025-08-02T04:47:10ZengElsevierNeuroImage: Clinical2213-15822025-01-0148103852Beyond language: empathy and emotion recognition deficits in primary progressive aphasiasGiulia Giacomucci0Alice Pieri1Valentina Moschini2Chiara Crucitti3Sonia Padiglioni4Carmen Morinelli5Giulia Galdo6Filippo Emiliani7Matilde Nerattini8Silvia Bagnoli9Assunta Ingannato10Sandro Sorbi11Benedetta Nacmias12Valentina Berti13Valentina Bessi14Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, ItalyUniversity of Florence, Florence, ItalyResearch and Innovation Centre for Dementia-CRIDEM, AOU Careggi, Italy; SOD Neurologia I, Dipartimento Neuromuscolo-Scheletrico e degli Organi di Senso, AOU Careggi, Florence, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, ItalyResearch and Innovation Centre for Dementia-CRIDEM, AOU Careggi, Italy; Regional Referral Centre for Relational Criticalities - Tuscany Region, ItalyResearch and Innovation Centre for Dementia-CRIDEM, AOU Careggi, Italy; SOD Neurologia I, Dipartimento Neuromuscolo-Scheletrico e degli Organi di Senso, AOU Careggi, Florence, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, ItalyDepartment of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, Florence, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, ItalyIRCCS Fondazione Don Carlo Gnocchi, Florence, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; IRCCS Fondazione Don Carlo Gnocchi, Florence, ItalyDepartment of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, Florence, Italy; Nuclear Medicine Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Corresponding authorsat: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla, 3, 50134 Florence, Italy.Although primary progressive aphasia (PPA) is considered a language disorder, increasing evidence points to the presence of social cognition impairments in PPA variants. The aims of this study were to explore empathy and emotion recognition deficits in the three PPA variants (sv-PPA, lv-PPA, nfv-PPA) and to identify their neural correlates.Eleven sv-PPA, 34 lv-PPA,11 nfv-PPA patients and 34 healthy controls (HC) were included in this study. Empathy was explored with the Interpersonal Reactivity Index (IRI) (Perspective Taking – PT, Fantasy – FT, Empathic Concern – EC, Personal Distress – PD), rated by caregivers before (T0) and after (T1) the onset of cognitive symptoms. Emotion recognition was evaluated with the Ekman 60Faces (EK-60F) Test and metabolic activity with [18F]FDG-PET.In all PPA variants, PT score was reduced from T0 to T1 (sv-PPA p = 0.014, lv-PPA p < 0.001, nfv-PPA p = 0.022) and PD score was increased (sv-PPA p = 0.033, lv-PPA p < 0.001, nfv-PPA p = 0.009). Only lv-PPA showed a decrease of FT score (p = 0.024), while EC was spared in all three variants. Sv-PPA patients had the worst performances in the EK-60F Test, followed by lv-PPA and, lastly, by nfv-PPA.Correlations between EK-60F scores and metabolic activity were found in sv-PPA and lv-PPA, highlighting the involvement of areas participating in the emotion recognition network: cingulate cortex, insula, temporal and orbitofrontal cortices and inferior frontal gyrus.All PPA variants exhibited impairments in cognitive empathy (PT) and heightened emotional contagion (PD). The most severe deficits in emotion recognition were shown by sv-PPA, while nfv-PPA was the less impaired variant.http://www.sciencedirect.com/science/article/pii/S2213158225001226 |
| spellingShingle | Giulia Giacomucci Alice Pieri Valentina Moschini Chiara Crucitti Sonia Padiglioni Carmen Morinelli Giulia Galdo Filippo Emiliani Matilde Nerattini Silvia Bagnoli Assunta Ingannato Sandro Sorbi Benedetta Nacmias Valentina Berti Valentina Bessi Beyond language: empathy and emotion recognition deficits in primary progressive aphasias NeuroImage: Clinical |
| title | Beyond language: empathy and emotion recognition deficits in primary progressive aphasias |
| title_full | Beyond language: empathy and emotion recognition deficits in primary progressive aphasias |
| title_fullStr | Beyond language: empathy and emotion recognition deficits in primary progressive aphasias |
| title_full_unstemmed | Beyond language: empathy and emotion recognition deficits in primary progressive aphasias |
| title_short | Beyond language: empathy and emotion recognition deficits in primary progressive aphasias |
| title_sort | beyond language empathy and emotion recognition deficits in primary progressive aphasias |
| url | http://www.sciencedirect.com/science/article/pii/S2213158225001226 |
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